HGH (Human Growth Hormone) has been marked as the secret to anti-aging. It can help with age-related issues, such as loss of muscle and bone mass. The best HGH supplements are designed to help you fight back against aging and improve your quality of life.

Various brands of the best HGH supplements are becoming popular as research surfaces about all the benefits of taking the best HGH supplements. There are now hundreds of products to choose from to help improve HGH.

We will talk about the four best HGH supplements we have worked with on the market, starting with GenF20 Plus.

The best HGH supplements have a unique set of advantages and disadvantages associated with their formula and expected results. We will dive deep into the products to present this information clearly and precisely before you decide which is best.

>>Check the best prices for GenF20 Plus

What Is the Human Growth Hormone?

Every living creature has some hormone responsible for growth and rejuvenation. In humans, this hormone is the human growth hormone (HGH). HGH is released and controlled by the pituitary gland.

HGH’s primary purpose in adolescents is to regulate growth and muscle build. Although its uses and benefits far stretch well into adulthood.

Some essential regulatory functions of HGH are:

• Body Composition
• Bodily Fluids
• Muscle and Bone Growth
• Cellular Regeneration
• Metabolism
• Cardiovascular Health

Healthy levels of HGH can be vital to keeping the body in check and performing optimally. This will help you live a longer, healthier, and happier life.

The Science Behind HGH Supplements

Research shows that our HGH levels drop dramatically in our early youth and progressively decline as we age.[1]  The drop in HGH is accompanied by weight gain, loss of muscle mass, and a decline in overall health. Many scientists are suggesting low HGH levels in aging adults can be blamed for many age-related illnesses.

HGH supplements rely on all-natural ingredients that should effectively synchronize with the body while increasing HGH production. The best HGH supplements aim to bring these HGH levels back up to an optimized level for improved performance.

Do HGH Supplements Really Work?

Fortunately, research backs the claims made by many of the best HGH supplements. One randomized, placebo-controlled study resulted in an almost immediate increase in HGH after taking the oral supplement.[2]

While research supports the effectiveness of an HGH supplement with increasing HGH and improving health, not all supplements are so effective.

>>Check the best prices for GenF20 Plus

Finding the Best HGH Supplements

If you have decided to pursue HGH supplements to get your body back in balance, then you want to choose the correct supplements. Unfortunately, there are a lot of companies that cut corners to produce cheaper HGH supplements to maximize their profits.

Cheap HGH supplements may not provide proper doses, lack adequate research, and skimp on the ingredients.

We have done the research to make your job a little easier. We have the top four best HGH supplements for you:

• GenF20
• HyperGH 14x
• Provacyl
• GenFX

Let’s learn more about the four best HGH supplements and how they can help you.

#1 Best HGH Supplements – GenF20

GenF20 brings us the top HGH supplement on the market, GenF20 Plus. One of the best HGH supplements, it aims to increase your HGH levels for optimal living and maximum comfort.

GenF20 is a reliable manufacturer run by a team of anti-aging experts who bring their knowledge and expertise to your home. GenF20 Plus crushes all the goals and expectations of a classic HGH supplement.

What Is GenF20 Plus?

GenF20 Plus is an all-natural HGH supplement that can help get your body back to peak health. Using potent amino acids and nutrients, this HGH supplement gives you all the tools you need to get your HGH back to healthy levels.

With GenF20 Plus, you can expect a variety of benefits, including:

• Improved Energy & Stamina
• Reversal of the Aging Process
• Better Libido & Sexual Performance
• More Lean Muscle Mass & Bone Density

GenF20 Plus is an ideal choice if you want benefits from one of the best HGH supplements in the market.

>>Check the best prices for GenF20 Plus

What Makes GenF20 Plus Unique?

Four factors gave GenF20 Plus a slight edge above the rest. Let’s look at what makes GenF20 a top-of-the-range choice.

1. Nutrient-Rich Formula

GenF20 Plus has a relatively simple yet unique formula that has proven robust and effective. The formula comprises sixteen key ingredients scientifically proven to deliver results. The HGH booster includes a combination of amino acids and nutrients to increase HGH levels.

2. Partner With Their Spray for Maximum Results

GenF20 offers a spray partner to go with their GenF20 Plus supplement. While this is not mandatory, it does deliver highly effective results when used together. This is an impressive conquest, considering how remarkable the supplement is on its own. The partner spray is just another option to maximize your results.

3. Supported by Clinical Research

Like the rest of the best HGH supplements in our list, GenF20 backs up its claims with thorough clinical research. This illustrates the effectiveness of the product. GenF20 has the will and interest to provide scientifically sound solutions to you and everyone who wants to experience the powerful benefits.

4. Money-Back Guarantee

Not all companies offer a money-back guarantee, but the ones that do, earn more respect from us.

The GenF20 money-back guarantee is a 67-day warranty. This means you can try out GenF20 Plus for up to two months; if you are unhappy, just return it for a full refund. You can try out GenF20 Plus with no financial risk or worry.

While GenF20 Plus has many more advantages, these are just some of the unique characteristics of the HGH supplement that make it stand out to our team.

The GenF20 Plus Formula

There are sixteen main ingredients in GenF20 Plus. Each ingredient is hand-chosen, thoroughly researched, and proven effective in supporting HGH levels and your quality of life.

• L-Arginine HCL
• L-Isoleucine
• L-Valine
• Astragalus Root
• L-Lysine HCL
• GABA
• L-Glutamine
• Deer Velvet Antler
• Pituitary Anterior Powder
• GTF Chromium
• Colostrum (10%)
• L-Glycine
• L-Tyrosine
• L-Ornithine HCL
• Tribulus Terrestris
• Phosphatidylcholine

The unique formula is loaded with tons of amino acids and vital nutrients to the body. Nothing in the formula list should harm you or negatively interact with your body.

>>Check the best prices for GenF20 Plus

GenF20 Plus – Mini F.A.Q.

Here we try to answer some important questions surrounding GenF20 to give you a little more information and insight into why it’s one of the best HGH supplements.

How Much Does GenF20 Plus Cost?

GenF20 Plus offers a variety of price packages to give you the best value possible. Here are the current prices:

• One-Month Package: $69.95
• Two-Month Package: 134.95
• Three-Month Package: $199.95
• Four-Month Package: $249.95
• Five-Month Package: $299.95
• Six-Month Package: $349.95

Remember that GenF20 offers a 67-day money-back guarantee. That means you can return your product for a full refund if unsatisfied with the results.

Are There Any Negative Side Effects?

There are no negative side effects associated with GenF20.

Do I Need a Prescription?

You do not need a prescription to order your GenF20 Plus.

How Do I Take GenF20 Plus?

You take two tablets twice daily.

How Soon Can I Expect Results?

Results may vary, depending on how much HGH you have in your body when you start taking GenF20. The less HGH you have, the longer it might take. You can expect up to three months for full-blown effects, though it may be much faster for some people.

Where Can I Buy GenF20 Plus?

You can purchase GenF20 Plus directly from their official website. This is the most secure and reliable place of purchase for this supplement.

>>Check the best prices for GenF20 Plus

#2 Best HGH Supplements – HyperGH 14x

HyperGH 14x is an all-natural HGH supplement from a reliable manufacturer that rightfully earns the second spot on our list of the best HGH supplements. HyperGH 14x makes its name for increasing HGH levels by up to 14 times. This is a rather impressive achievement by utilizing great ingredients.

What Is HyperGH 14x?

HyperGH 14x is a mixture of natural amino acids and nutrients that increase of HGH. This can be a supplementary solution to HGH deficiencies that will continue to benefit you for as long as you take the product.

Here are some benefits of continued use of HyperGH 14x:

• Improved Muscle Mass
• Increased Energy for More Intensive Workouts & Sexual Performance
• Reduce Fat

What Makes HyperGH 14x Unique?

HyperGH 14x has earned second on our list of best HGH supplements. Here are three key reasons HyperGH 14x ranked so well on our scales:

1. Hyper Focus on Bodybuilding

HyperGH 14x places importance on bodybuilding and weight training. The bodybuilding emphasis makes this the perfect choice for anyone trying to bulk up and gain significant muscle mass. While there are other benefits (such as improved sleep and more energy), this is the priority for our team.

2. Two Optimal Doses a Day

Like GenF20, HyperGH 14x has split its doses to twice a day. This was scientifically researched to allow you to perform at your best.

The first dose you take in the morning before exercise. This gives your body the boost and energy it needs to excel at the gym. The second dose you take in the evening when you are winding down. This dose helps get your circadian rhythm on track for a solid night’s sleep.

3. Money-Back Guarantee

If you are unsatisfied with your results, HyperGH 14x also offers a money-back guarantee. You can try out this supplement risk free for up to 67 days before you return it for a full refund.

We could talk all day about what makes HyperGH 14x one of the best HGH supplements, but for now, you’ll have to take our word for it.

>>Check the best prices for HyperGH 14x

The HyperGH 14x Formula

There are fourteen active ingredients in HyperGH 14x. Each ingredient plays a crucial role in stimulating the increase of HGH within your body.

• Phosphatidylcholine
• Deep Antler Velvet
• L-Glycine
• L-Glutamine
• GTF Chromium
• L-Valine
• Pituitary Anterior Powder
• Tribulus Terrestris
• Astragalus Root Extract
• GABA
• L-Arginine
• L-Tyrosine
• L-Ornithine
• Colostrum

The formula is an assortment of amino acids and nutrients vital to proper bodily functioning. By giving your body these nutrients, you are allowing it to function at total capacity.

>>Check the best prices for HyperGH 14x

HyperGH 14x–Mini F.A.Q.

These questions should provide more detail and clarification on HyperGH 14x.

How Much Does Hypergh 14X Cost?

HyperGH 14x currently offers three different packages. The more you buy, the better your price.

• One-Month Package: $69.95
• Three-Month Package: $199.95
• Six-Month Package: $349.95

How Soon Can I Expect Results?

It may take up to three months for full effects to kick in. However, some people will witness the results much faster.

How Do I Take Hypergh 14X?

You just take two capsules twice daily–two in the morning and two in the evening.

Do I Need a Prescription?

You do not need any prescription to order your HyperGH 14x.

Are There Any Side Effects?

There have been no adverse side effects reported for HyperGH 14x.

Where Can I Purchase Hypergh 14X?

You can buy HyperGH 14x directly from their official website.

>>Check the best prices for HyperGH 14x

#3 Best HGH Supplements – Provacyl

Provacyl is an HGH supporter and testosterone booster. Provacyl comes from a reliable, transparent, and trustworthy manufacturer and was created by a team of experts to deliver high-quality results.

What Is Provacyl?

Provacyl is an HGH and testosterone-boosting supplement. By approaching the problems we face as we age from two angles (low HGH and low testosterone), this supplement is perfect for any man who wants to get back his prime.

Here is what Provacyl can do for you:

• Increase Testosterone
• Increase HGH Production
• Boost Energy Levels
• Improve Your Sex Drive

This is a multi-purpose, high-quality supplement made for the needs of the average male.

What Makes Provacyl Unique?

Provacyl stands out as a unique option in our best HGH supplements for three main reasons:

1. HGH Support With Testosterone-Boosting Qualities

Rather than focusing solely on HGH levels, Provacyl also includes testosterone-boosting ingredients. Low testosterone levels also play a critical role in age-related illnesses. You can increase both HGH and testosterone production for more impressive results.

2. Focus On Countering “Male Menopause”

Women are not the only ones that go through troubling years with their mental and physical health. Provacyl sets its sights on countering the effects of “male menopause” (andropause). Andropause can be detrimental to male health. Provacyl addresses this issue and helps your body fight back.

3. Money-Back Guarantee

Provacyl also comes with a 67-day money-back guarantee. This allows you to try Provacyl risk-free. You can decide for yourself if this is something for you.

Provacyl has a lot of other advantages as one of the best male enhancement supplements available, but these are the three most notable to our team.

>>Check the best prices for Provacyl

The Provacyl Formula

There are 23 active ingredients in Provacyl. The high ingredient list is due to the dual purpose of the supplement, addressing both HGH and testosterone levels.

• GABA
• Zinc
• Vitamin K2
• Magnesium
• L-Lysine
• D-Aspartic Acid
• L-Glycine
• Swedish Flower Pollen
• Ginseng
• Vitamin D3
• L-Arginine
• Anterior Pituitary
• Vitamin B6
• Glutamine
• Longjack (Tongkat)
• Acai Fruit
• Soy Phosphate Complex
• Muira Puama
• Ginkgo Biloba
• Hypothalamus
• DHEA
• L-Tyrosine
• L-Pyroglutamate

You might recognize some of these ingredients from the previous HGH supplements on the list. But Provacyl has a unique twist with several additional vitamins and minerals to enhance testosterone and overall health.

Provacyl – Mini F.A.Q.

Why is Provacyl part of our best HGH supplements list? Here are some important questions that provide a little more information about Provacyl, where to buy it, and how much it costs.

How Much Does Provacyl Cost?

The current Provacyl prices are as follows:

• One-Month Package: $59.95
• Three-Month Package: $154.95
• Six-Month Package: $268.95
• Twelve-Month Package: $570.45

The larger the quantity you purchase, the better the price.

Are There Any Adverse Side Effects?

Like the best HGH supplements on our list, there are no adverse side effects with Provacyl.

Do I Need a Prescription?

Provacyl uses only natural, herbal vitamins and minerals. This means you do not need a prescription.

How Do I Take Provacyl?

You take four pills a day. It is suggested that you follow the detailed instructions that come with your order.

How Long Until Provacyl Kicks In?

Provacyl could show full effects in as little as one month of taking the supplement daily.

Where Can I Buy Provacyl?

You can buy Provacyl directly from the official website.

>>Check the best prices for Provacyl

#4 Best HGH Supplements – GenFX

Last but not least, we have GenFX coming in at the fourth spot of our best HGH supplements. GenFX is a quality supplement that should not be overlooked, although earning last place.

What Is GenFX?

GenFX is an HGH releaser designed to help you fight all the effects of aging. GenFX supplies your body with amino acids and vitamins that can revitalize and bring you back to your youth.

Here is what you can expect with extended use of GenFX:

• Feel Younger Than Ever
• Lose Weight Faster
• Gain More Muscle

Like most of the best HGH supplements, GenFX comes with a lot of advantages and heavy promises and we can speak from experience; it certainly delivers on those promises!

What Makes GenFX Unique?

Here are two of the most important things from our experience with GenFX.

1. Doctor-Endorsed

GenFX comes highly recommended by some world-renowned doctors. These experts share their opinion and scientific research regarding the HGH releaser. The results shared are auspicious.

2. Money-Back Guarantee

Like the other HGH supplements on the list, GenFX offers a money-back guarantee. With no financial risk, this 67-day warranty allows you to try out GenFX to see what the hype is about.

While there is much more to note about GenFX and the effectiveness of the HGH releaser, these are the two most important aspects that make GenFX a unique and powerful option.

>>Check the best prices for GenFX

The GenFX Formula

There are seventeen all-natural ingredients in GenFX. These ingredients are a combination of effective, powerful, and healthy amino acids and nutrients:

• L-Lysine
• Soy Phosphatides Complex
• L-Leucine
• L-Glycine
• Panax Ginseng Powder
• L-Pyroglutamate
• L-Threonine
• L-Arginine
• Anterior Pituitary
• L-Glutamine
• L-Valine
• Phytosterol Complex
• L-Tyrosine
• L-Methionine
• L-Phenylalanine
• Hypothalamus
• L-Isoleucine

This carefully conducted formula has proven to pass all the tests. It is an effective combination of ingredients that increases HGH levels to feel youthful and beautiful once again.

GenFX– Mini F.A.Q.

What makes GenFX one of the best HGH supplements? Here are some frequently asked questions surrounding GenFX and its effects.

How Much Does GenFX Cost?

Here are the current prices of GenFX:

• One-Month Package: $49.95
• Three-Month Package: $124.85
• Six-Month Package: $199.70
• Twelve-Month Package: $399.40

Do I Need a Prescription to Order This Supplement?

No. You do not need a prescription for GenFX.

Are There Any Negative Side Effects?

There are no reported adverse side effects from GenFX.

How Do I Take GenFX?

You take two capsules a day.

How Long Until Results Become Noticeable?

Results can become evident in a few weeks, but may take up to two months for full effects to kick in.

Where Can I Buy GenFX?

You can purchase GenFX directly from their official website. Unfortunately, this is the only reliable source of the supplement.

>>Check the best prices for GenFX

These Best HGH Supplements Help You Feel Alive Again

Choosing between the best HGH supplements can be daunting with how many supplements are circulating the market. We hope to make this easier by discussing the four best supplements today.

Each of these supplements has unique characteristics that stand above and beyond other competing supplements. GenF20 earned the top spot on our list, but the other three supplements discussed would not disappoint.

Whichever you decide, we hope you are ready to begin the journey right back to your youth! You will surely feel energized, revitalized, and ready to take on anything!

Related Articles:

• Benefits of L-Theanine
• Foods That Can Increase Your Testosterone
• Guide to NAD+: Is It Possible to Reverse Aging
• Does Working Out Increase Testosterone

Resources:

1. Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. [Updated 2019 Oct 7]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279163/
2. Tam CS, Johnson WD, Rood J, Heaton AL, Greenway FL. Increased Human Growth Hormone After Oral Consumption of an Amino Acid Supplement: Results of a Randomized, Placebo-Controlled, Double-Blind, Crossover Study in Healthy Subjects. Am J Ther. 2020 Jul/Aug;27(4):e333-e337. doi: 10.1097/MJT.0000000000000893. PMID: 30893070; PMCID: PMC6732240.

Plenty of people bust their tails in the gym and eat right. However, not everybody gets the same results. Why is that? We’re here today to discuss some possible answers. We’ll give you a comprehensive GenF20 Plus review to help you understand how this 100% natural HGH releaser could potentially help you improve your physique.

HGH, or human growth hormone, plays a crucial role in many bodily processes, including muscle growth and strength gains. The issue is that no two bodies are precisely the same. Some people produce more than enough HGH to sustain muscle growth, while others don’t.

For many individuals, no matter how hard they work out or how clean they eat, their physical capabilities have a ceiling. This fact can be incredibly frustrating if you want to make considerable gains in the gym. The truth is your body could be betraying you by not producing adequate levels of HGH.

A high-quality HGH releaser can improve the health of your body’s vital HGH-producing cells leading to significant gains in lean muscle production. Is GenF20 Plus capable of that? What do GenF20 Plus reviews say?

HGH Is Critical To Muscle Growth And Fat Burning

Let’s start this GenF20 Plus review by describing what HGH is. HGH is the primary hormone responsible for sustainable, healthy growth in humans. The pituitary gland produces all of the GH or growth hormone in humans. This tiny gland in the brain is sometimes called the “master gland” due to its hormone-producing abilities.

This hormone is abundant in young people and children because they’re still growing. However, once we develop fully, the pituitary gland will naturally produce less growth hormone, making maintaining peak physical health more difficult.

Adequate levels of HGH are crucial to:

• Healthy body composition
• Muscle growth
• Bone density
• Metabolic function
• Fat regulation
• Joint health
• Cell regeneration

As HGH and its sister hormone IGF-1 (insulin-like growth factor 1) production declines, you will experience significant degenerative effects. Of course, these effects vary from person to person. Factors like lifestyle and diet can affect health outcomes.

In this GenF20 Plus review, we’ll discuss in depth the relationship between IGF-1 and HGH below. But first, let’s look at what exactly GenF20 Plus is and what it may be able to do for your health.

>>Check the best price for GenF20 Plus

What Exactly Is GenF20 Plus?

As with other GenF20 Plus reviews, it can be described as an HGH releaser. That means it stimulates the pituitary gland to produce more HGH naturally. It’s not synthetic HGH, nor does it contain HGH, and it comes with none of the negative side effects some other treatments might.

According to some GenF20 Plus reviews, it uses an all-natural proprietary formula with 16 ingredients, from essential amino acids to herbals acting as HGH precursors. And it’s available in both tablets and as an oral spray.

GenF20 Plus claims to:

• Enhance hgh production 
• Promote lean muscle growth 
• Increase strength 
• Diminish body fat 
• Boost energy levels 
• Reduce muscle recovery time 
• Encourage joint health 

The product features some excellent evidence to support these claims. First, this all-natural HGH releaser has the support of medical professionals, including a board-certified doctor who happens to be the director of the NYU Men’s Health Center, Dr. Steven Lamm.

Secondly, a clinical trial found that GenF20 Plus effectively promoted HGH production in participants. More on that later.

Could GenF20 Plus help you tack on lean muscle while reducing body fat? This GenF20 Plus review will tell you all that and more.

>>Check the best price for GenF20 Plus

GenF20 Plus Review: Does It Work?

Yes, GenF20 Plus works. It can do what it says it will do, and we’ll tell you why. But first, we’ll state that this product isn’t perfect. With that in mind, let’s check the pros and cons to give you a complete overview of this GenF20 Plus review.

Pros

• Improves HGH production
• 100% natural ingredients
• No known negative side effects
• 67-day money-back guarantee
• Clinical study backs efficacy
• Supported by medical professionals
• Can increase lean muscle mass
• Reduces body fat

Cons

• May be expensive for some
• Only available for purchase online
• Not suitable for vegans

The pros heavily outweigh the cons. However, like so many other GenF20 Plus reviews say, it may not be suitable for all.

It’s not the cheapest product on the market, but it’s certainly on the high end of the quality spectrum. And the proprietary formula isn’t vegan-friendly, as it contains some animal products, which we’ll discuss in the ingredients section.

According to other GenF20 Plus reviews, if you’re looking to optimize your gains in the gym, add lean muscle mass, and reduce belly flab, then GenF20 Plus can certainly help you.

GenF20 Plus Review — 7 Critical Ingredients

Any high-end health supplement, which GenF20 Plus is, should have a transparent list of clinically-backed ingredients. We’re happy to report that all of the 16 ingredients in GenF20 Plus show clinical efficacy in naturally promoting HGH production and, subsequently, muscle growth and fat reduction.

We’ll give you a snapshot of some key ingredients in this GenF20 Plus review. If you’d like a complete list of ingredients, check out the official GenF20 Plus webpage.

>>Check the best price for GenF20 Plus

1. GABA – 200 mg

Gamma-Aminobutyric Acid, or GABA for short, is a non-protein amino acid. It acts as a neurotransmitter that carries messages from the brain to nerve endings throughout the body. It naturally works to reduce stress as well as fear and can improve sleep quality.

As with many GenF20 Plus reviews, we found a 2012 clinical study determined that GABA supplementation stimulates the pituitary gland to produce more HGH.[1]

2. GTF Chromium – 0.4 mg

Glucose tolerance factor chromium, aka GTF chromium, is an essential trace mineral. This mineral stabilizes blood glucose levels and improves insulin sensitivity making it critical to metabolic health.

A clinical study on animals showed that GTF chromium supplementation significantly reduced body fat percentage.[2]

3. L-Tyrosine – 400 mg

L-Tyrosine is an amino acid that promotes the production of neurotransmitters in the body. It is vital in producing protein and enzymes that induce natural muscle growth. This nonessential amino acid also improves levels of dopamine, which can improve mood and focus.

A 2020 clinical trial found that optimal daily L-Tyrosine intake stimulated participants’ growth hormone production.[3]

4. L-Lysine – 400 mg

L-Lysine is an essential amino acid the body doesn’t produce. We must consume it through diet. It’s vital for producing collagen, a substance that aids in bone density and cartilage health.

When L-Lysine combines with L-Arginine, another amino acid in GenF20 Plus, it has powerful HGH stimulating properties. A clinical trial of 16 male athletes showed that combing L-Lysine and L-Arginine in daily supplementation yielded massive increases in HGH production.[4]

5. L-Arginine HCL – 520 mg

L-Arginine is a potent amino acid that promotes protein synthesis in the body, resulting in rapid muscle growth. It exists in many protein-rich foods like chicken, fish, and beef. As we stated above, when L-Arginine and L-Lysine are combined, you can see supercharged HGH-promoting effects.

A 2017 clinical study determined that L-Arginine supplementation significantly increased HGH and IGF-1 Production.[5]

>>Check the best price for GenF20 Plus

6. Colostrum – 200 mg

Colostrum, or “first milk,” is a compound a mother produces in breast milk. It’s primarily responsible for supplying infants with the HGH-stimulating nourishment they need for the rapid growth they will experience.

According to a clinical review, there is significant evidence that colostrum promotes HGH production in humans.[6]

7. Deer Antler Velvet – 200 mg

This extract taken from deer antlers is popular among athletes recovering from strenuous activities. It has healing properties for joints and cartilage in humans. It’s been famous for athletes in Asia for centuries.

Now, clinical evidence shows that it’s no placebo, even in other GenF20 Plus reviews. One clinical study found that Deer Antler Velvet significantly reduced recovery time and aided energy metabolism.[7]

Ingredients Make the Difference

The all-natural ingredients in GenF20 Plus are critical to the potency of this HGH releaser. It’s important to note that every ingredient is perfectly dosed, based on clinical research. Clinically-backed doses can effectively deliver robust muscle growth and fat burning with no negative side effects. 

The clinical trials back up the formula. That’s a massive checkmark in favor of GenF20 Plus.

>>Check the best price for GenF20 Plus

GenF20 Plus Review—The Clinical Study

Not many other HGH releasers, if any, have been put to the test of a double-blind clinical trial. Yet, a double-blind clinical trial showed astounding results in favor of GenF20 Plus. 

Let’s break down what happened here.

The Double-Blind Trial

The study comprised 61 participants between 35-65 years old. A computer algorithm randomized the participants into two groups. Half of the participants received a daily dose of GenF20 Plus, while the other half got a placebo.

HGH levels can be challenging to quantify. However, IGF-1, the sister hormone to HGH, can be measured relatively easily. And IGF-1  levels are a great indicator of HGH levels. The study focused on measuring IGF-1 levels in the participants.

So, researchers took the IGF-1 levels of each participant before beginning supplementation and then again after 84 days or 12 weeks. The results were stunningly powerful.

The Results

Participants over 40 showed 28% higher IGF-1 levels, indicating a massive gain in HGH production.[8]

But not only that—Participants receiving GenF20 Plus showed even more improvements like:

• Increased muscle mass 
• Reduced waistlines 
• Lowered body fat 
• Increased energy 

These results make a massively clear case in favor of the efficacy of GenF20 Plus. A double-blind clinical trial is the creme de la creme of tests for a health supplement, and this product has it. Only the best of the best supplements have this kind of backing.

But if you don’t care for scientific studies, check out what some GenF20 Plus users said.

>>Check the best price for GenF20 Plus

GenF20 Plus Review—Customer Testimonials

We met and spoke with loads of people using GenF20 Plus. Nearly everyone we talked to had nothing but great things to say.

Let’s check out a few customer testimonials here.

Alex R. in Boise, Idaho, said:

“I’ve always been a gym rat. But once I hit 35, I found it nearly impossible to build strength or muscle mass. I was in the gym 4 days a week, but my belly was growing, and my biceps were shrinking. I started using GenF20 Plus on the advice of a friend. After about a month, it was like a switch flipped. Suddenly, I could work out longer and harder. I dropped a ton of belly flab and started to pack on muscle. I’m still using Gen20 Plus to this day.” 

Marlon C. in Annapolis, Maryland, said:

“I like to look good and want my muscles to be toned. It’s been tough to get where I want to be. I train, eat right, and get enough sleep, but the results don’t follow. I started taking GenF20 Plus 2 months ago, and I’m seeing the best gains of my life. I plan on using this product forever.”

Jordan M. in Tacoma, Washington, said: 

“I started using GenF20 Plus 4 years ago. I was 40 at that time and in the worst shape of my life. After about 5 weeks of using this supplement, I felt and looked much better. I’m still using it after all this time, and I’m in the best shape of my life. I’ve even recommended GenF20 Plus to my brother and father. They’re also getting great results.”

This GenF20 Plus review could feature nothing but positive customer testimonials. That’s how many we heard, but we won’t do that to you.

If you’d like to check out some more customer reviews, head to the official GenF20 Plus website.

GenF20 Plus Review: Who Makes GenF20 Plus?

Leading Edge Health manufactures and distributes GenF20 Plus. This company has been a mainstay in the health supplement industry for over 20 years, producing several all-natural health supplements for women and men. Read more on the official Leading Edge Health webpage today.

GenF20 Plus Review: How To Take GenF20 Plus

As we mentioned above, and other GenF20 Plus Reviews, GenF20 Plus is available as a tablet or an oral spray. It’s possible to combine both products to achieve optimal results. The recommended dose is four tablets a day. That means two in the morning and two at night.

You can apply the oral spray after consuming the tablets for a supercharged dose. However, don’t overuse either the tablets or the oral spray.

If you stick to the recommended doses, there are no known negative side effects. However, some users who double or triple the dosage can experience stomach pain and indigestion.

>>Check the best price for GenF20 Plus

How Long Does GenF20 Plus Take To Work?

Take GenF20 Plus twice daily to get the most efficient results. After about two weeks, many users will notice significant changes.

However, it’s important to note that this product is no overnight fix. Some may need to wait five-eight weeks to allow the formula to go to work before expecting actual results. And to maintain healthy HGH production fueling muscle growth, you must remain consistent with GenF20 Plus intake.

The results are cumulative, so you’ll see huge gains with more time. Once you stop taking GenF20 Plus, your results will begin to fade until you return to pre-supplement HGH levels.

Where To Buy GenF20 Plus

We recommend buying GenF20 Plus directly from the manufacturer. This product is only available for sale online. Get it at the official GenF20 Plus website.

That’s where you’ll find the 100% money-back guarantee. And that’s where you’ll get free shipping anywhere within the United States.

How Much Does GenF20 Plus Cost?

GenF20 Plus isn’t the cheapest product on the market. But often, you have to pay a little for quality. However, It’s significantly more affordable than many alternative HGH-promoting treatments.

You’ll save significantly by buying in bulk.

• One-Month Supply—$69.95 
• Two-Month Supply—$134.95
• Three-Month Supply—$199.95
• Four-Month Supply—$249.95 
• Five-Month Supply—$299.95
• Six-Month Supply—$349.95

On a per-bottle basis buying a bigger supply will save you a ton of money. If you can swing it, that will offer the best value.

And remember, each order comes with a 100% money-back guarantee when you buy from the manufacturer. You could always try it, and if you don’t like it, return your empty or partially used bottles within 67 days of purchase for a full refund.

GenF20 Plus Review—Is It Right For You?

If you’re struggling to add muscle mass, maintain muscle mass, or gain strength, then GenF20 Plus could help you. The clinical trial, the powerful ingredients, the doctor’s approval, and the customer testimonials prove that GenF20 Plus works.

HGH is vital to muscle growth, fat loss, and overall health. Just like other GenF20 Plus reviews, we believe GenF20 Plus shows enough evidence to prove it can raise your HGH production naturally and safely. That will take your physique to whole new levels.

>>Check the best price for GenF20 Plus

Related Articles:

• Benefits of L-Theanine
• Foods That Can Increase Your Testosterone
• Guide to NAD+: Is It Possible to Reverse Aging
• Does Working Out Increase Testosterone

Resources

1. Powers M. GABA supplementation and growth hormone response. Med Sport Sci. 2012;59:36-46. doi: 10.1159/000341944. Epub 2012 Oct 15. PMID: 23075553.
2. Zha LY, Xu ZR, Wang MQ, Gu LY. Effects of chromium nanoparticle dosage on growth, body composition, serum hormones and tissue chromium in Sprague-Dawley rats. J Zhejiang Univ Sci B. 2007 May;8(5):323-30. doi: 10.1631/jzus.2007.B0323. PMID: 17542060; PMCID: PMC1859878.
3. Mahmoud S, Saad M, El-Shehawi AM, Farrag F, Abo Ghanima MM, Dawood MAO, Shukry M. Promoting Effect of L-tyrosine Supplement on New Zealand Rabbit Bucks’ Performance and Reproduction Through Upregulation of Steroidogenic Markers. Front Vet Sci. 2020 Oct 14;7:605. doi: 10.3389/fvets.2020.00605. PMID: 33195497; PMCID: PMC7592602.
4. Suminski RR, Robertson RJ, Goss FL, Arslanian S, Kang J, DaSilva S, Utter AC, Metz KF. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sport Nutr. 1997 Mar;7(1):48-60. doi: 10.1123/ijsn.7.1.48. PMID: 9063764.
5. Suminski RR, Robertson RJ, Goss FL, Arslanian S, Kang J, DaSilva S, Utter AC, Metz KF. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sport Nutr. 1997 Mar;7(1):48-60. doi: 10.1123/ijsn.7.1.48. PMID: 9063764.
6. Playford RJ, Macdonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr. 2000 Jul;72(1):5-14. doi: 10.1093/ajcn/72.1.5. PMID: 10871554.
7. Chen JC, Hsiang CY, Lin YC, Ho TY. Deer Antler Extract Improves Fatigue Effect through Altering the Expression of Genes Related to Muscle Strength in Skeletal Muscle of Mice. Evid Based Complement Alternat Med. 2014;2014:540580. doi: 10.1155/2014/540580. Epub 2014 Feb 20. PMID: 24701242; PMCID: PMC3950920.
8. Sonawane, Navneet, et al. “Effect of genf20 plus on Serum IGF-1 Levels in Healthy Adults: A Rando: OAJCT.” Open Access Journal of Clinical Trials, Dove Press, 25 Mar. 2015, https://www.dovepress.com/effect-of-genf20-plus-on-serum-igf-1-levels-in-healthy-adults-a-random-peer-reviewed-fulltext-article-OAJCT.

Testosterone is a sex hormone produced by males (and in smaller amounts in females) that influences sexual function, muscular mass and fertility. The amount of testosterone in a person’s body decreases with age, but medical problems, lifestyle choices, and other factors can alter how much of this hormone is present in the body.

It takes more than the occasional workout to keep your body healthy and your testosterone balanced. Your doctor may recommend more exercise, testosterone replacement therapy, or most likely, a change in diet, to assist your body maintain a healthy balance and combat low testosterone. Keep reading for a list of testosterone boosting foods. 

Key Takeaways: Testosterone Levels and Diet

• Testosterone has many health benefits, such as lowering risks of certain diseases and boosting your sex drive and bone and muscle health.
• Testosterone-boosting foods are often high in zinc and magnesium.
• You can boost your testosterone levels naturally by reducing alcohol consumption, exercising regularly, and maintaining a balanced diet.
• You can also boost your t levels by taking testosterone replacement therapy.
• Certain foods, like processed foods, will lower your testosterone levels.

Testosterone Boosting Foods

Here are the foods that can boost testosterone levels into your body:

• Seafood
• Leafy vegetables
• Whole grain products
• Certain nuts
• Ginger
• Olive oil
• Onions and garlic

01: Seafood

Certain seafood, like oysters, are aphrodisiacs high in zinc and contain more zinc per serving than other foods. Zinc is important for boosting your sex drive, boosting sperm count, and maintaining a healthy amount of dopamine.

Oysters are also rich in protein, vitamin B12, selenium, magnesium, and D-aspartic acid and are a good source of omega-3 fatty acids. Omega-3 fatty acids can improve heart health and prevent heart diseases, which can better blood flow and help treat erectile dysfunction [1].

Like oysters, shrimps are also rich in zinc; they’re also rich in vitamin D, iodine, and iron. According to researchers, men with more vitamin D in their bodies also have more testosterone. Much more, shrimp is low in fat, making it the ideal testosterone-boosting seafood for those watching their weight.

Salmon and tuna, two commonly eaten fish, are other seafood that will boost your testosterone. Naturally-caught salmon has 75% more vitamin D than their manufactured counterparts. Tuna is a great source of vitamin D and is one of the most budget-friendly seafood you can buy for your testosterone boost.

02: Leafy Vegetables

Certain types of vegetables can boost your testosterone- leafy vegetables.

One vegetable is spinach— Popeye’s favorite vegetable, but why does he love it so much? One reason could be spinach being a natural source of magnesium, which boosts testosterone. Spinach is also high in vitamin B6 and iron. Not only that, but spinach can also help boost your immune system and muscle cells.

Another leafy green that can boost your testosterone is kale. 

Kale has become popular in recent years. One reason is that it’s high in all sorts of vitamins and minerals, like vitamins A and C. Vitamin A helps boost your testosterone, while vitamin C helps produce testosterone.

03: Whole Grain Products

As a healthier alternative to white bread, whole grain products have one added interesting benefit: they boost testosterone. Whole grain products are high in fiber, making you feel fuller while not putting on any more weight. If you gain too much weight, your testosterone will lower.

Some whole grain products you can eat are brown rice, oats, whole-wheat, fortified cereals, and bread. These products are good sources of magnesium. 

04: Certain Nuts

Not all nuts are equal in boosting testosterone. So, which nuts are the kinds that will increase your testosterone levels?

The Brazil nut has a high amount of selenium. Selenium is great for activating genes and pathways enhancing testosterone production [2]. It’s good for fighting oxidative stress, supporting the production of thyroid hormones, reducing blood sugar levels, and reducing inflammation.

Another nut to boost your testosterone is the macadamia nut. Macadamia nuts are low in polyunsaturated fats (reduce testosterone) and high in monounsaturated fats (boost testosterone).

The last nut that’ll boost your testosterone is the tiger nut. Tiger nuts can double your testosterone levels [3] . Known as earth almonds, they can enhance libido and contain a high amount of zinc and vitamins C and E.

05: Ginger

This spice contains vitamins C and E and lutein, tannin, beta-carotene, lycopene, and more. Ginger contains crucial manganese, zinc, selenium, and copper elements.

Ginger enhances testosterone by increasing LH production, improving blood cholesterol levels in the testes, normalizing blood glucose, reducing oxidative stress and lipid peroxidation in the testes, increasing testicular weight, and recycling testosterone receptors.

06: Olive Oil

Olive oil can improve your reproductive health by boosting serum testosterone levels. You can experience an increase in luteinizing hormones, stimulating cells in the testes to produce testosterone. This oil is abundant in monounsaturated fats and vitamin E. These two elements can reduce heart disease and cancer.

07: Onions and Garlic

Despite their stout smells, these two foods can increase your testosterone levels.

Onions enhance testosterone levels by improving the production of luteinizing hormones, the hormones responsible for sexual development and functioning.[4] It also has high levels of flavonoids, a natural plant chemical that helps to increase testosterone levels.

Garlic, meanwhile, has a compound known as S-allyl cysteine that increases testosterone production. The S-allyl cysteine is a water-soluble organosulfur compound found in garlic extract, also known to boost testosterone. 

This compound is also known to protect against cardiovascular disease and hypertension.

Summary

Testosterone can be found in many things. Seafood, leafy vegetables, whole grain products, certain nuts, ginger, olive oil, onions, and garlic can boost testosterone production and give you other health benefits.

How to Boost Testosterone Naturally

With testosterone boosting foods come other natural testosterone boosters, too. You can reduce your alcohol consumption, exercise regularly, and maintain a balanced diet.

01: Reduce Alcohol Consumption

It’s fine to sip alcohol occasionally, but consistent consumption can lower your testosterone levels. For one, alcohol consumption can negatively impact your hypothalamus and pituitary gland. Your testosterone levels can decrease in as little as 30 minutes after sipping on a drink.

One study had healthy men drink a pint of whiskey per day for 30 days and had their testosterone levels compared to chronic alcoholics. The healthy men had lower T-levels on the third day and were around the same as the alcohol-drinkers’ levels by the end of the month. Those are the short-term effects.

Heavy drinkers are more likely to have poorer testicular functions than moderate drinkers. They’re also more likely to experience low libido, erectile dysfunction, and low testosterone levels. Alcohol can also interfere with LH, FSH, and GnRH release.

02: Exercise Regularly

Does working out increase testosterone? That answer is yes.

Regular exercise already has many health benefits, but certain exercises can give you free testosterone. It’s the major promoter of muscle building and growth. 

Resistance exercises, like weightlifting, are best for boosting your testosterone in both the short and long term. In one study, men who did resistance exercises three days a week for four weeks had more testosterone levels right after a workout and over time [5] .

It’s not the same way for everyone. One study showed a 21.6% increase in testosterone levels for the male body but only a 16.7% increase for women after a 30-minute weightlifting session [6]. Another study states that the rise in testosterone levels in women may only be temporary.

Some exercises, like cardio and running, do not raise testosterone production but lower it. One 2016 study showed that 20-minute intervals containing eight seconds of cycling could lower testosterone levels in women [7]. That’s because those exercises, also known as endurance exercises, break down muscle tissues.

There are also specific natural foods that will help you if you want to learn how to lower your testosterone levels. 

03: Maintain a Balanced Diet

You need a variety of vitamins and minerals to stay healthy. That’s why maintaining a balanced diet is crucial for boosting your testosterone.

It’s best to eat a balance of carbs, fats, and protein. Carbs help optimize testosterone level during resistance training. Healthy fats can also help your testosterone and give you other health benefits. Proteins, meanwhile, will help you maintain healthy levels and help you lose any unhealthy fat. Less body fat means more testosterone.

Summary

You can naturally boost your testosterone by reducing your alcohol consumption, exercising regularly, and maintaining a balanced diet.

Which Foods Increase Testosterone the Most?

Many foods boost your testosterone, but certain foods will boost it more than others. If you want the most amount of testosterone, you should try eating zinc rich foods, like:

• Seafood
• Leafy vegetables
• Whole grain products
• Certain nuts
• Ginger
• Olive oil
• Onions and garlic

Foods That’ll Increase Testosterone in Females

Testosterone production isn’t just important for men — females need it, too. Besides boosting libido and muscle building, testosterone also improves your mood and memory. To prevent low testosterone in women, try eating:

• Organic, free-range eggs (rich in protein, vitamin B6, and omega-3)
• Almonds and pumpkin seeds (rich in zinc, magnesium, and protein)
• Leafy vegetables like kale and spinach (rich in magnesium, vitamin B6, and iron)
• Wild oily fish like salmon and mackerel (rich in omega-3 and protein)
• Black beans, kidney beans, and pinto beans (rich in protein, zinc, B vitamins, and magnesium)
• Pomegranate juice (lowers blood pressure)

What Are Foods That Decrease Testosterone?

Now that we’ve gone over testosterone-boosting foods and how you can boost it, we should go over foods that’ll decrease testosterone. So, here are some testosterone killing foods:

• Soy and soy-based products (high in phytoestrogens)
• Vegetable oil (loaded with polyunsaturated fatty acids)
• Flaxseed (high in lignins and omega-3 fats- flaxseed effects on testosterone)
• Processed foods (high in sodium and added sugar)
• Certain nuts, like walnuts (high in polyunsaturated fatty acids)

Summary

To increase your testosterone levels, try eating more organic foods high in protein, magnesium, vitamin B6, and zinc. Avoid foods that are high in phytoestrogens, lignins, and polyunsaturated fats.

How Can You Increase Testosterone Levels Quickly?

You can increase testosterone production naturally by eating certain foods such as whole grain products, ginger, leafy vegetables and seafood. 

You can also increase your testosterone naturally by reducing alcohol consumption, exercising regularly, and maintaining a balanced diet. As for increasing it quickly, you can take some vitamin D supplements or hormone treatments, such as:

• Pills
• Injections
• Patches
• Gel

However, hormone treatments must be prescribed by a licensed physician. 

Summary

You can have the best testosterone by eating certain foods, reducing alcohol consumption, exercising regularly, maintaining a balanced diet, and, if a doctor agrees your case is severe, undergoing hormone treatments.

Hormone Treatment

If a doctor determines you have a medical need for it, there are hormone treatments you can take to boost your testosterone. 

You can take many kinds of testosterone replacement therapy, such as:

• Pills (taken twice daily)
• Injections (given weekly)
• Patches (attached to the skin)
• Gel (applied to the skin)

Remember to take a blood test and wait for a diagnosis before taking these hormone treatments for testosterone.

Summary

With a doctor’s prescription, you can take hormone treatments like pills, injections, patches, and gel to increase your T-levels.

FAQ

We’ve compiled a list of the most popular questions asked about testosterone. 

What Foods Are Bad For Testosterone?

Foods that are bad for testosterone are soy/soy-based products, vegetable oil, flaxseeds, processed foods, and certain nuts (like walnuts).

How Can I Raise My Testosterone Levels Fast?

You can raise them quickly by eating foods that’ll boost testosterone, reduce alcohol consumption, exercise regularly, and maintain a balanced diet. You can also increase testosterone levels by taking hormone treatments (under medical supervision), like pills, injections, patches, and gel.

Does Masturbation Decrease Testosterone?

No, masturbation doesn’t affect testosterone production.

Do Bananas Increase Testosterone?

Yes. Bananas have an enzyme called bromelain, which boosts testosterone levels.

Conclusion

The food you consume has all sorts of health benefits, and one of those benefits is improving testosterone levels. 

You can boost your testosterone levels by eating certain foods, reducing alcohol consumption, exercising regularly, maintaining a balanced diet, and taking hormone treatments. Testosterone, after all, has many benefits to keep you functioning.

References

1. Colussi G;Catena C;Novello M;Bertin N;Sechi LA; “Impact of Omega-3 Polyunsaturated Fatty Acids on Vascular Function and Blood Pressure: Relevance for Cardiovascular Outcomes.” Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/27692558/.
2. Y;, Shi L;Song R;Yao X;Ren. “Effects of Selenium on the Proliferation, Apoptosis and Testosterone Production of Sheep Leydig Cells in Vitro.” Theriogenology, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/28257863/.
3. Verpeut, Jessica L, et al. “Citrus Aurantium and Rhodiola Rosea in Combination Reduce Visceral White Adipose Tissue and Increase Hypothalamic Norepinephrine in a Rat Model of Diet-Induced Obesity.” Nutrition Research (New York, N.Y.), U.S. National Library of Medicine, June 2013, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808124/.
4. Banihani, Saleem Ali. “Testosterone in Males as Enhanced by Onion (Allium Cepa l.).” Biomolecules, MDPI, 21 Feb. 2019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406961/.
5. Timón Andrada R;Maynar Mariño M;Muñoz Marín D;Olcina Camacho GJ;Caballero MJ;Maynar Mariño JI; “Variations in Urine Excretion of Steroid Hormones after an Acute Session and after a 4-Week Programme of Strength Training.” European Journal of Applied Physiology, U.S. National Library of Medicine, https://pubmed.ncbi.nlm.nih.gov/17051372/.
6. Kumagai, Hiroshi, et al. “Increased Physical Activity Has a Greater Effect than Reduced Energy Intake on Lifestyle Modification-Induced Increases in Testosterone.” Journal of Clinical Biochemistry and Nutrition, The Society for Free Radical Research Japan, Jan. 2016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706091/.
7. Kong, Zhaowei, et al. “Comparison of High-Intensity Interval Training and Moderate-to-Vigorous Continuous Training for Cardiometabolic Health and Exercise Enjoyment in Obese Young Women: A Randomized Controlled Trial.” PLOS ONE, Public Library of Science. https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0158589.

Dealing with anxiety disorders can leave people desperate for any form of relief. Unfortunately, people with mental illnesses like anxiety are also more likely to try self-medicating, and many turn to Adderall to manage their symptoms. 

Does Adderall benefit people with anxiety — or does the drug simply worsen the symptoms? 

This article answers the question while covering what Adderall is, why it is used, and alternative treatments for ADHD and anxiety. 

Key Takeaways: Adderall and Anxiety

• Adderall is a drug used for treating ADHD
• ADHD is typically diagnosed in children, but adult ADHD is also very common
• Adderall can worsen anxiety if you don’t also have co-occurring ADHD.
• Self-medicating with Adderall could lead to addiction
• There are alternative treatments like nootropics available to treat symptoms of both ADHD and anxiety

What Is Adderall?

Adderall is a stimulant drug often prescribed in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is a combination of amphetamine, dextroamphetamine, and the inactive ingredients colloidal silicon dioxide, cornstarch, magnesium stearate, and compressible sugar, among others. 

Although adults can also have ADHD, most people develop the disorder as children or teens. ADHD symptoms include [1]: 

• Lack of attention
• Difficulty concentrating
• Disorganization
• Forgetfulness
• Regularly losing things

How Does Adderall Work?

As a drug used to treat ADHD, how Adderall works is by acting as a central nervous system (CNS) stimulant that increases the production and concentration of the norepinephrine and dopamine neurotransmitters in your brain. 

Dopamine plays an essential role in feelings of pleasure, while norepinephrine is an excitatory hormone and neurotransmitter responsible for boosting brain function. 

Adderall Side Effects

As with all stimulant drugs, the side effects of Adderall vary from person to person and could range from mild jitters to severe sleeping issues. 

Adverse symptoms caused by Adderall use include: 

• High blood pressure
• Trouble sleeping
• Weight loss
• Loss of appetite
• Dizziness
• Nervous behavior
• Increased heart rate

Since Adderall can elevate your heart rate, severe side effects of Adderall use could include events like a heart attack or stroke [2].

Adderall Contraindications

As with all potent drugs, Adderall has several contraindications, such as [3]: 

• Monoamine oxidase inhibitor treatment for depression or other mental illnesses as this could raise their blood pressure to dangerous levels 
• Cardiovascular disease
• Arteriosclerosis
• Glaucoma
• Hyperthyroidism
• Severe hypertension
• People with a history of drug abuse
• People with co-occurring conditions like depression or bipolar disorder

Before taking any drug, especially Adderall, you should always consult with a medical professional to discuss possible side effects and risks considering your medical history. 

Does Adderall Help Anxiety?

No, Adderall does not help with anxiety or similar mental health disorders like panic attacks or depression. Using Adderall to treat anxiety could worsen your symptoms as the effects of the drug could enhance your feelings of agitation, nervousness, and paranoia. 

Can You Get Prescribed Adderall for Anxiety?

Although some people may be prescribed Adderall to treat an anxiety disorder that exists alongside attention deficit hyperactivity disorder, stimulant drugs like Adderall and Ritalin are rarely prescribed as a treatment for anxiety on their own.

Should I Take Adderall If I Have Anxiety?

If you have a mental health condition or one of the many types of anxiety disorders diagnosed in Americans each year, you should not use Adderall as a treatment, whether prescribed by a doctor or not. 

Not only can Adderall worsen the symptoms of anxiety, but it has a high potential for abuse and subsequent addiction. 

Co-Occurring Anxiety with ADHD and Narcolepsy

Anxiety disorder usually doesn’t occur on its own. Many people who suffer from the condition also have co-occurring disorders like depression, ADHD, panic disorders, or even narcolepsy. 

Around 25% of people with ADHD also have anxiety [4], and another 35% of people with narcolepsy show anxiety symptoms, too [5]. This means people who use Adderall for their ADHD could also be experiencing the negative impact the drug has on their anxiety.

Does Adderall Cause Anxiety?

Not necessarily, since Adderall is often prescribed for ADHD patients to help them calm down and focus. Despite Adderall not directly causing an anxiety disorder, it could make pre-existing anxiety symptoms worse [6]. 

Since one of the neurotransmitters triggered by using Adderall is an excitatory hormone, using the drug could not only get you more worked up and make your anxiety worse, it could contribute to the development of a panic disorder and related panic attacks when used to treat anxiety symptoms. 

Adderall and ADHD Anxiety

According to the Anxiety and Depression Association of America, nearly half of the population of American adults diagnosed with attention deficit hyperactivity disorder (ADHD) also have some type or form of anxiety [7].

Does Adderall Help With ADHD Anxiety?

In many ways taking Adderall can help with anxiety symptoms if they are related to your ADHD. Struggling with ADHD means you might feel like you have no ownership over your brain, and you are constantly subject to the thoughts and impulses that pop into your head. 

Although Adderall and anxiety aren’t a good mix on their own, using the drug to deal with your ADHD could help your mind feel clear enough to reduce many of the symptoms of anxiety you would previously have had no control over. 

Which ADHD Medication Causes The Least Anxiety?

The stimulant with the least side effects is methylphenidate or Ritalin, most often prescribed for children and teenagers and least likely to cause anxiety.

Managing Adderall Related Anxiety

The mood disturbances caused by using or abusing Adderall can vary in severity but are often quite challenging to cope with. Thankfully there are several ways to deal with Adderall-related anxiety, the best of which are discussed below. 

Anti-Anxiety Medications

Anti-anxiety medication is often the first choice when managing anxiety caused by Adderall use, dealing with anxiety-related mental health issues, or simply when people feel anxious for no apparent reason. 

The most commonly prescribed drugs for quick treatment of anxiety symptoms are called benzodiazepines and include: 

• Xanax (alprazolam)
• Klonopin (clonazepam)
• Librium (chlordiazepoxide)
• Valium (diazepam)
• Ativan (Lorazepam)

Some medications for high blood pressure also have off-label benefits for treating anxiety or panic disorders.

Adderall Alternatives

If you are struggling with a mental health condition or are looking for other drugs than Adderall to help with your ADHD, there are a range of natural treatment options that may be more beneficial to your long-term recovery, especially considering Adderall abuse may eventually lead to addiction. 

The alternative supplements for treating the symptoms of ADHD or anxiety are called nootropics. They are natural supplements that act as cognitive enhancers and can boost your motivation, focus, memory, and learning abilities to help counteract the adverse effects of these disorders.

One of the best nootropics available, Mind Lab Pro, is a Universal Nootropic with research-backed ingredients like citicoline and phosphatidylserine, both of which are proven to enhance brain regeneration while boosting your mental energy levels, thought clarity, and attention. 

Another excellent option, Performance Lab Nootropics, contains four nootropic ingredients, including maritime pine bark and L-tyrosine, both of which significantly improve your cognitive function and boost the sectors of your brain most often affected by ADHD.  

FAQ 

Below are some of the most commonly asked questions about Adderall and anxiety.

Is Adderall Addictive?

Using Adderall for an extended period or taking it as a dual diagnosis treatment without a doctor’s prescription could lead to addiction and the possible development of other substance use disorders. 

Adderall abuse can quickly cause your body to become dependent on the drug, meaning you can’t function normally without it. Once you develop this physical and psychological dependence, you may start experiencing withdrawal symptoms between doses, leading to a full-blown Adderall addiction. 

For many, an Adderall crash can become so severe it leads to suicidal thoughts, extreme mood swings, and depression. 

Getting addiction treatment if you believe you are abusing or are addicted to the drug is essential, and if you think your loved one may be misusing Adderall or prescription stimulants of any kind, you should encourage them to seek counseling and addiction treatment

addiction treatment to help them recover. 

Does Adderall Have a Calming Effect?

Most ADHD drugs like Adderall are stimulants, meaning they increase your energy and feelings of excitement, confidence, and focus. If you don’t have ADHD, Adderall will only rile you up, not calm you down. 

Can Stimulants Help With Anxiety?

In most cases, stimulants like Adderall and caffeine will only result in increased anxiety symptoms. These drugs are not prescribed for the treatment of any mental health disorder, only for the treatment of ADHD and similar conditions.

Does Adderall Help With Stress and Anxiety?

No, Adderall increases the negative feelings associated with these conditions as it is a central nervous system stimulant, not a sedative. 

What Is the Best Drug For Severe Anxiety?

Severe anxiety is a mental health disorder best treated with prescription medication like Xanax for immediate relief. Long-term recovery may involve therapy alongside other longer-acting drugs. 

Does Adderall Help With Depression?

No, using or abusing Adderall could lead to withdrawal symptoms that could worsen your depression and mental health by producing negative feelings and thoughts.

Conclusion

Trying to treat a mental illness can be challenging. Although Adderall use is adequate in managing ADHD, it does not benefit people with anxiety. 

If you have an anxiety disorder, you should seek therapy and medication made specifically for your condition, as in many cases misusing Adderall could lead to addiction and a range of adverse effects on your mental health.

And if you’re looking for a holistic, natural aid to relieve your symptoms, nootropics could help you combat ADHD and anxiety without using synthetic drugs like Adderall.

References:

1. K;, Magnus W;Nazir S;Anilkumar AC;Shaban. “Attention Deficit Hyperactivity Disorder.” National Center for Biotechnology Information, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/28722868/#:~:text=The%20symptoms%20begin%20at%20a,being%20forgetful%2C%20and%20losing%20things.
2. Sichilima, Tangu, and Michael J Rieder. “Adderall and Cardiovascular Risk: A Therapeutic Dilemma.” Paediatrics & Child Health, Pulsus Group Inc, Mar. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2690554/.
3. Martin, Dustin. “Amphetamine.” StatPearls [Internet]., U.S. National Library of Medicine, 3 Aug. 2021, www.ncbi.nlm.nih.gov/books/NBK556103/.
4. TA;, Reimherr FW;Marchant BK;Gift TE;Steans. “Adhd and Anxiety: Clinical Significance and Treatment Implications.” Current Psychiatry Reports, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/29152677/.
5. Fortuyn HA;Lappenschaar MA;Furer JW;Hodiamont PP;Rijnders CA;Renier WO;Buitelaar JK;Overeem S; “Anxiety and Mood Disorders in Narcolepsy: A Case-Control Study.” General Hospital Psychiatry, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/20114128/.
6. Barr, Jeffrey L, et al. “Withdrawal from Chronic Amphetamine Produces Persistent Anxiety-like Behavior but Temporally-Limited Reductions in Monoamines and Neurogenesis in the Adult Rat Dentate Gyrus.” Neuropharmacology, U.S. National Library of Medicine, Nov. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC2946460/.
7. “Adult Adhd (Attention Deficit Hyperactive Disorder).” Adult ADHD (Attention Deficit Hyperactive Disorder) | Anxiety and Depression Association of America, ADAA, adaa.org/understanding-anxiety/related-illnesses/other-related-conditions/adult-adhd.

Do you feel like you’re going nowhere? Perhaps you have no energy, no sense of joy in your life, no libido, or no progress at the gym or in your favorite sport. Maybe you’re experiencing all four of these problems.

If so, chances are you have low testosterone. Even though women have much lower requirements for testosterone than men, it’s still an essential hormone for your overall health and vitality. So what can we do to restore testosterone as women?  

Key Takeaways

• Many women struggle with testosterone insufficiency, particularly post-menopausal women.
• Testosterone plays vital roles in maintaining optimal health and well-being, including maintenance of muscle mass, libido, and some cognitive functions.
• Too much testosterone is a feature of PCOS, a condition associated with weight gain and infertility.
• Like men, zinc and strength training can significantly increase testosterone levels.
• On the other hand, licorice, spearmint, and the contraceptive pill can lower testosterone, interfering with your muscle gain goals.
• Hormone replacement therapy can effectively increase muscle growth.

What Is Low Testosterone in Women?

It is estimated that a total testosterone level of 25ng/mL or less indicates a testosterone deficiency in women under 50 years old. This cutoff moves to 20ng/mL or less for women over 50, when you are expected to be past menopause. For free testosterone, the criteria are hormone levels of under 1.5pg/mL and 1pg/mL for women under and over 50, respectively [1]. 

If you have polycystic ovary syndrome (PCOS), your priority may be how to lower testosterone as you have excess testosterone. In this case, correcting metabolic dysregulation through a healthy diet, exercise, and drugs such as metformin can restore normal testosterone levels. 

The oral contraceptive pill, particularly formulations with progestin, is able to reduce testosterone production in the adrenal glands and prevent it from becoming more potent [2]. 

What Stimulates Testosterone in Women?

There are several ways to stimulate testosterone production in women. For example, zinc has been shown to double the levels of testosterone in postmenopausal women, from 25ng/mL to 50ng/mL. This led to improvements in sexual interest and natural lubrication [3]. 

As described below, resistance (strength) training may slightly, but meaningfully, increase testosterone levels in women. 

What Causes Low Testosterone in Women?

The biggest causative factor for low testosterone levels in women is menopause. The ovaries produce most testosterone, so all sex hormones levels drop below the normal range when the ovaries become too depleted. If you are in the over 40 age group, it may be time for a testosterone test. 

Perhaps you are too young to think about menopause, but instead, you’re on the oral contraceptive pill. Progestin, a common ingredient, can lower testosterone in women by reducing production of hormones in the ovaries. It also increases sex hormone binding globulin, which binds to the hormones and prevents them from working [2]. 

Women can be affected by testosterone killing foods too, just like men. If you enjoy licorice candy or tea, we hate to be the bearer of bad news, but it can reduce testosterone. Clinical studies show that licorice can be an effective treatment for PCOS, where testosterone levels are too high. In one clinical trial, levels fell from 27.8 to 17.5ng/dL in two months, but they quickly returned to normal afterward [4]. 

Another common herbal remedy that we often enjoy as a tea is spearmint. Although it tastes refreshing, it has been found to reduce testosterone in women, too [5].

If you’ve been using flaxseed as an omega-3 fatty acid source or to balance female hormones, don’t worry. Research on women with PCOS shows that flaxseed effects on testosterone are insignificant, but it can improve your metabolic health [6]. 

Summary

Menopause, taking the oral contraceptive pill, and herbal medicines such as licorice and spearmint can all lower testosterone in women. 

What Are the Symptoms of Low Testosterone in Women? 

There are several key symptoms of low testosterone to look out for as a woman: 

• An impaired ability to build muscle mass. Even though testosterone isn’t seen as important for women, it plays an essential role in building and maintaining muscle mass. This is an area of concern if you are older, in order to prevent age-related frailty [7]. 
• Depression is a common consequence of both low and high testosterone levels in women. Beyond sadness, depression features an inability to feel pleasure and a deep, low mood [8]. 
• Poor libido, in particular low arousal and sexual desire. 
• Cognitive impairments, especially in spatial awareness, can be a consequence of low testosterone, too.  
• Increased body fat, while combining estrogen and testosterone in hormone replacement therapy can prevent weight gain in post-menopausal women [7]. 

Summary

Low testosterone levels cause a range of mental, musculoskeletal, and endocrine (hormonal) problems, from difficulty building muscle to cognitive disturbance. 

Diagnosis

As testosterone is transported through the bloodstream, you will need a blood test to determine your testosterone levels. Your level of DHEA, the precursor to testosterone, should also be measured. These will be compared to the healthy reference ranges, and with your symptoms. It is possible to receive testosterone therapy even if your hormone levels are normal, if you are showing symptoms. 

For many years, physicians have called for testing testosterone and appropriate hormone therapy as soon as a perimenopausal woman complains of fallen sexual desire. Diagnosis may also be important if you have been taking estrogen replacement therapy, but it’s not working for you [1].

Summary 

If you are experiencing symptoms such as impaired libido and declining performance at the gym, it may be best for you to test for androgen deficiency.

How To Increase Testosterone in Females

There are several ways to correct an androgen deficiency and increase testosterone levels if you are a woman. They may involve hormone replacement therapy, nutrition, or lifestyle changes. 

Testosterone Therapy

The most convenient way to increase your testosterone levels is through testosterone replacement therapy. You can take it orally, or topically as a patch or cream. The latter two allow for a slower, more sustained release, similar to natural testosterone production [9]. 

An alternative to replacing testosterone is taking DHEA, the precursor to testosterone and other sex hormones. It has long been prescribed in cases of adrenal insufficiency, where your adrenal glands cannot pump out enough hormones. Some preparations can even be bought over the counter [1]. 

Foods That Increase Testosterone

As written above, zinc can dramatically boost testosterone so foods that increase testosterone will include those rich in zinc. Shellfish, both crustacean and mollusk, red meat, particularly beef liver, and certain root or leafy vegetables are good sources of zinc. Atlantic oysters, beef, and king crab come out on top [10]. 

Theoretically, some cruciferous vegetables may keep up your levels of testosterone. Indole-3-carbinol and diindolylmethane (DIM), found in sources such as watercress and broccoli sprouts, inhibit the enzyme aromatase. This may contribute to androgen deficiency by “stealing” testosterone, and converting it into estrogen [11]. 

How Can a Woman Increase Her Testosterone Naturally?

If you want to try more natural ways to boost testosterone than just replacing hormones, you may be wondering, does working out increase testosterone? Research demonstrates that strength training is able to produce a small, yet significant, rise in free testosterone levels for women. Although much smaller, it persists for longer than in men, until at least 30 minutes after exercise [12]. 

Summary

Testosterone treatment options include directly replacing lost hormones, which can be topical or oral preparations. Milder cases of deficiency may benefit from zinc supplements or cruciferous vegetables, as well as strength training. 

FAQ

What are the most important things we need to know about low testosterone levels in women? 

What Are the Symptoms of Low Testosterone in Females?

Low testosterone contributes to weight gain as body fat, prevents you from building muscle, and can contribute to depression, fatigue, and poor libido. 

How Can a Woman Increase Her Testosterone Level?

Women can increase testosterone levels through hormone therapy, such as the use of testosterone patches or cream. 

What Is the Main Symptom of Low Testosterone?

The number one complained-about symptom of low testosterone in women is a lack of sexual desire, which can lead to both relationship and health problems if left unaddressed.  

How Does Testosterone Affect the Female Body?

Women produce testosterone to assist in muscle growth and maintenance, as well as maintaining a healthy libido, energy level, and mood balance. It is important to remember that women are more sensitive to testosterone’s effects, too. Too much testosterone can, however, worsen weight gain and depression, which we can see in cases of PCOS. 

What Happens When You Take Testosterone as a Woman?

Testosterone therapy in women causes increased muscle mass, which is often the intended effect. A trial of healthy women found they developed more muscle mass with use of a cream, at an increase of 923 grams instead of 135 grams. As for performance, only aerobic fitness improved, not strength [9]. 

Conclusion 

Many women struggle with low testosterone levels, which increases in prevalence as we get older. The cause can be anything from menopause or ovarian failure, down to taking the oral contraceptive pill or enjoying too much licorice. Fortunately, there are treatment options to suit a range of causes, from changing your diet to testosterone replacement therapy. 

References:

1. Guay A, et al. (2003). Testosterone insufficiency in women: fact or fiction? bumc.bu.edu/sexualmedicine/publications/testosterone-insufficiency-in-women-fact-or-fiction/ 
2. Rasquin Leon LI, Anastasopoulou C, Mayrin JV. Polycystic Ovarian Disease. [Updated 2021 Jul 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459251/
3. Mazaheri Nia, Leila et al. “Effect of Zinc on Testosterone Levels and Sexual Function of Postmenopausal Women: A Randomized Controlled Trial.” Journal of sex & marital therapy vol. 47,8 (2021): 804-813. doi:10.1080/0092623X.2021.1957732 
4. Armanini, Decio et al. “Licorice reduces serum testosterone in healthy women.” Steroids vol. 69,11-12 (2004): 763-6. doi:10.1016/j.steroids.2004.09.005 
5. Grant, Paul. “Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial.” Phytotherapy research : PTR vol. 24,2 (2010): 186-8. doi:10.1002/ptr.2900
6. Haidari, Fatemeh et al. “The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial.” Nutrition journal vol. 19,1 8. 24 Jan. 2020, doi:10.1186/s12937-020-0524-5 
7. Davis, Susan R, and Sarah Wahlin-Jacobsen. “Testosterone in women–the clinical significance.” The lancet. Diabetes & endocrinology vol. 3,12 (2015): 980-92. doi:10.1016/S2213-8587(15)00284-3
8. Stanikova, Daniela et al. “Testosterone imbalance may link depression and increased body weight in premenopausal women.” Translational psychiatry vol. 9,1 160. 7 Jun. 2019, doi:10.1038/s41398-019-0487-5 
9. Hirschberg, Angelica Lindén et al. “Effects of moderately increased testosterone concentration on physical performance in young women: a double blind, randomised, placebo controlled study.” British journal of sports medicine vol. 54,10 (2020): 599-604. doi:10.1136/bjsports-2018-100525 
10. Solomons, Noel W. “Dietary Sources of Zinc and Factors Affecting Its Bioavailability.” SAGE Journals, (2001) journals.sagepub.com/doi/abs/10.1177/156482650102200204.
11. Licznerska, Barbara E et al. “Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines.” European journal of nutrition vol. 52,5 (2013): 1483-92. doi:10.1007/s00394-012-0455-9 
12. Vingren, Jakob L et al. “Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women.” Steroids vol. 74,13-14 (2009): 1033-9. doi:10.1016/j.steroids.2009.08.002 

Nicknamed the living fossil tree, ginkgo biloba has been around for 200 million years. Its leaves and seeds were an ancient remedy, used for millennia to treat dozens of ailments. But its medicinal value was only acknowledged by modern clinicians in the last few decades.

Sources say it can heal wounds, improve your vision, memory and concentration, improve blood circulation, and reduce depression. It was also the first treatment for asthma in traditional Chinese medicine.

But does folk medicine belong in the past? Or was ancient wisdom right all this time? 

Here we delve into the facts about ginkgo, and bring answers to light for you.

Key Takeaways: Ginkgo Biloba

• Ginkgo biloba has been used for thousands of years due to its many claimed health benefits.
• Effects of ginkgo biloba are said to support lowering blood pressure, positively impact mental health, respiratory health and detoxify cells.
• It could be a cognitive enhancer due to its neuroprotective effects, helping with memory retention.
• Further research is needed for the use of ginkgo biloba to prevent dementia.
• Ginkgo comes in many forms and you should know how to use it properly.
• There are many possible side effects of taking ginkgo biloba, especially if you are epileptic or taking blood thinner medication.

Overview: Ginkgo Biloba

Ginkgo biloba is a tree native to China also known as the maidenhair tree. Now, it is considered a medicinal tree and is one of the most popular herbal supplements in the world.

It’s been said to have an array of incredible uses during its long history, that include: 

• Healing skin 
• Improving circulation 
• Treating vertigo
• Helping with sexual dysfunction 

Ginkgo is most often associated with brain health, granting it claims to an array of cognitive benefits, and improvements in mental wellbeing [1].

The alleged health benefits have attracted attention from supplement companies and clinicians in recent years. Its bioactive compounds have been tested, assessing how the dietary supplement can be used to improve the lives of those with impairments and benefit the wellbeing of healthy people [1].

History

The ginkgo biloba tree has prehistoric roots—it’s thought to look the same as it did when dinosaurs were on earth. The living trees are themselves ancient; a ginkgo tree in China is estimated to be 3,500 years old [2]!

Its medicinal uses were recorded in Chinese medicine about 2,000 years ago. Ancient botanists experimented first with ginkgo seeds, later to discover its leaves could play an important function in treating major health problems, like lung and heart disease [3].

The tree’s healing properties were neglected for a long time, until 1964 when it caught the eye of a scientist. Since then, ginkgo biloba extracts have been introduced in modern and alternative medicine to support cognition, memory, and reduce symptoms of depression or anxiety [3].

How Does It Work?

​​There are many active ingredients of clinical importance contained in ginkgo biloba, especially in its seeds and leaves. 

Ginkgo seeds have recently been discovered to have potent antibacterial properties that can treat acne. This was an important finding for the development of topical medicines for people with psoriasis, dermatitis, and eczema [3].

Its leaves have major antioxidant compounds with neuroprotective effects. They have the ability to remove free radicals from the body, which are harmful molecules that occur everywhere, both naturally and from toxins in the atmosphere. Our bodies require support to clear themselves from free radicals before they damage cells [4].

The active components in ginkgo biloba leaves can also support the cardiovascular system by improving circulation, strengthening the walls of small blood vessels, reducing high blood pressure, and preventing blood clotting. Stimulating blood flow can help protect nerve cells if they do not have enough oxygen [4].

Extracts of the herb may also promote wound healing, have benefits for the respiratory system, concentration problems and help to sharpen up memory [4].

Due to its uses for brain health, it was tested as a hopeful treatment for Alzheimer’s disease. But antioxidants alone do not appear adequate for impacting serious neurological issues like Alzheimer’s disease [4].

Health Benefits of Ginkgo Biloba 

Ginkgo Biloba could have the following 10 health benefits:

1. Boosts brain function and memory
2. Improves anxiety and depression
3. Reduces symptoms of psychiatric diseases
4. Improves heart health and circulation
5. Relieves premenstrual symptoms
6. Reduces vertigo
7. Supports vision and eye health
8. Fights inflammation
9. Improves asthma and symptoms of COPD
10. Contains powerful antioxidants

Boosts Brain Function and Memory

Ginkgo biloba extract is said to have therapeutic benefits, especially for improving memory and cognition [5].

Its antioxidant effect gives it a neuroprotective factor, which is what is thought to improve memory. Protecting brain cells can support brain health, naturally helping sharpen up the mind, especially in otherwise healthy individuals looking for a boost [4].

We should not put too much faith in the herb for treating cognitive impairment, though. Although it can support brain function to a point, ginkgo biloba extract is not meant to be touted as a treatment for serious cognitive issues caused by stroke, or as a reliable way to reduce cognitive decline caused by Alzheimer’s disease [4].

Improves Anxiety and Depression

Ginkgo biloba extract can help the brain to balance hormones, and thereby, reduce symptoms of anxiety and depression, according to science [6].

It was shown to effectively improve the mental health of older adults who had depressive symptoms. When combined with other antidepressant medications, taking ginkgo can magnify the therapeutic benefits of psychiatric drugs according to the study [7].

Reduces Symptoms of Psychiatric Diseases

Ginkgo is meant to be helpful for psychiatric patients for two reasons: firstly, it is said to be therapeutic for people with attention deficit hyperactivity disorder (ADHD) and schizophrenia. This is because it can stabilize hormones in the brain, improving focus. 

Second, it has been examined as a way to reduce neural damage caused by psychiatric drugs—a side effect often seen in patients who have been medicated for a long time [8]. 

A side effect of antidepressants is antidepressant-induced sexual dysfunction—the healing and relaxing effect of ginkgo could be one way to help improve symptoms [9].

Improves Heart Health and Circulation

Ginkgo has anticoagulant properties—meaning the active ingredients can act as blood thinners, stopping blood from clotting and improving blood flow. The extract has also been used as a way to improve circulation in people who experience cold hands and feet [10].

Another circulatory problem, called intermittent claudication, is when blood clots in the legs. The condition is common among older adults and can be very painful. As a blood thinner, Ginkgo has been tested as a treatment for the condition, and although it makes a difference to the symptoms, scientists say, not to a clinically significant degree [11].

Overall, the anticoagulant effect can improve vein health, positively impacting the cardiovascular system. Another effect of biloba is the dilation of blood vessels, which can reduce high blood pressure and support blood flow [12].

The herb has been known to improve sexual dysfunction for this reason also. Because it can improve circulation, it’s been said to increase blood flow to the penis, and is likely to support sexual function for women, too [13].

Relieves Premenstrual Symptoms

A randomized, placebo-controlled trial with women suffering from severe PMS showed that ginkgo extract significantly reduces the physical and psychological effects [14].

Premenstrual syndrome affects millions of women and can cause serious discomfort. Research on the positive impact of ginkgo was seen as a significant finding for the support of women with painful PMS. Ginkgo’s ability to improve PMS is likely due to its support with balancing hormones in the brain [14].

Reduces Vertigo

Vertigo is a feeling of dizziness and nausea caused by damage to nerves that connect to the inner ear. It can be a side effect of people who suffered a stroke [15].

Although ginkgo’s been tested as a way to treat vertigo, it’s unclear if the extract has a significant impact on the condition. A couple of small-scale studies have assessed the impact—some found noticeable improvements but others found no difference between the placebo group and the group taking standardized ginkgo [16] [17].

Supports Vision and Eye Health

Sharp vision relies on healthy nerves and good blood circulation. Due to ginkgo’s alleged impact on those areas of health, it is said to improve people’s vision and eyesight. There’s some research in this regard with glaucoma patients [18].

Age-related macular degeneration, which means the deterioration of sight with age, is another possible area of research with ginkgo extract.

Fights Inflammation

Inflammation of neurons and the nervous system is the body’s reaction to damage caused by toxins, viruses, and injury. Left untreated, inflammation can cause damage to cells. The anti-inflammatory effects of ginkgo can help prevent damage [4].

Improves Asthma and Symptoms of COPD

Asthma and chronic obstructive pulmonary disease (COPD) are complex and unique respiratory conditions, however, a key cause of both is chronic inflammation in the lungs [19]. ​​Anti-inflammatory therapies, like ginkgo, are central to long-term asthma management, according to experts [20].

Research shows that ginkgo biloba extract may be used as a complement to steroid treatment for asthma [21].

Contains Powerful Antioxidants

As explored in other sections, there’s a fair amount of evidence showing the antioxidant power of ginkgo biloba extract and leaves. The ability to reduce oxidative stress, which is damage to neurons caused by toxins, is the reason it has memory and mind-boosting qualities [22].

Ginkgo nuts are good for detoxing, and a popular ingredient in Chinese cooking.

Roasted ginkgo seeds are shown to have antioxidant power comparable with ginkgo biloba standardized extract, dried leaf extracts, and commercial ginkgo capsules [23].

The Best Ginkgo Biloba Memory Nootropics 

Did we mention, ginkgo is a popular nootropic ingredient? There are various nootropic stacks blended as nootropics for motivation and nootropics for memory. Here we provide a summary of some leading brands producing ginkgo biloba supplements.

Qualia Mind

Qualia Mind is said to be a winner for both physical and mental performance. It contains five nootropic herbal ingredients, seven neuro-boosting vitamins, six adaptogens, five amino acids, and choline, which is important for brain and cell health. Most of the ingredients, like ginkgo, are likely to help you concentrate and improve your memory. 

Pros

• Sharpens up memory
• Boosts mental energy
• Reputable brand
• Contains many B vitamins

Cons

• Dozens of ingredients; unclear if all of them are equally beneficial
• Expensive

BrainPill

Besides ginkgo, BrainPill dietary supplements include vitamins, amino acids, and other nootropic compounds such as l-theanine, which is great for boosting memory. The ingredients are said to have other benefits too, such as reducing cognitive decline. 

Pros

• Improves memory
• Reduces brain fog
• Relatively affordable
• Simple dosage instructions

Cons

• Contains only four nootropic ingredients. The average blend would contain around ten herbs

Check out our comprehensive BrainPill review to read more about this leading popular nootropic.

If you’re a serious neurohacker and shopping around for the best supplement, read our research on other products via the Mind Lab Pro review and Performance Lab Nootropics review. They include more information about nootropics and alternatives to ginkgo products.

How To Take Ginkgo Biloba 

Depending on your preference and needs, you can take ginkgo in a few different forms, including:

• Capsules
• Tablets
• Liquid extracts
• Leaves and teas
• Topically
• In blended nootropic supplements/stacks

Dosing

In studies, healthy adults have safely taken between 120 mg – 240 mg a day in divided doses. 

How Much Ginkgo Biloba Should I Take for Memory?

Tried and tested dosages for patients who have memory problems and mild cognitive impairment is 120mg – 240 mg daily, taken in two to three doses [24].

Ginkgo Biloba Side Effects 

Common side effects of ginkgo biloba:

• Diarrhea
• Dizziness / Weakness
• Constipation
• Headache
• Nausea/vomiting

Unusual side effects of ginkgo:

• Seizures
• Allergic skin reactions
• Bleeding disorders
• Dermatitis from contact with skin
• Impaired fertility [25]
• Restlessness
• Stomach upset
• Subdural hematoma or higher risk of stroke
• Ventricular arrhythmia/palpitations
• Spontaneous bleeding [26]

The serious side effects listed here are rare, especially in healthy adults. However, there is a chance that they’re underreported, so further research about them is needed [26]. 

Use of ginkgo biloba should always be done under the supervision of a healthcare provider.

Precautions and Warnings

Ginkgo biloba comes with various precautions and warnings because it can prevent blood clotting and has a potentially toxic effect on the body. To ensure that it’s right for you, take note: 

It’s not advisable to take ginkgo when pregnant or breastfeeding, and if taken close to childbirth it can cause excess bleeding when in labor. For the same reason, anyone who is about to undergo surgery should avoid taking ginkgo biloba [24]. 

More research is needed to fully understand the effects during pregnancy and on breast milk.

People who take blood thinners, either as pain relief or for a cardiovascular issue, should avoid ginkgo supplements due to its anticoagulant effects. Doubling up on these drugs may cause a potentially dangerous bleeding disorder [24].

Ginkgo nuts can be poisonous and should never be eaten raw. Cooked and roasted ginkgo nuts can be eaten but should always be prepared well.

Seizure threshold lowering drugs, such as ginkgo, can create conditions in the brain that bring on seizures. It is particularly risky for those who are already prone to seizures, like epileptic individuals.

When it comes into contact with the skin, ginkgo has been known to cause allergic skin reactions that has developed into contact dermatitis [26]. 

Research with animals shows ginkgo is a possible carcinogen, which means the seeds and leaves can be toxic at high doses [25].

Interactions

There are various possible interactions with ginkgo and other drugs, mostly with anti-platelet drugs or blood-thinning medications [24].

Certain antidepressants can also interact with ginkgo biloba, possibly making them more or less effective. Taking ginkgo with serotonin reuptake inhibitors (SSRI) can increase the risk of serotonin syndrome, which is a potentially fatal reaction [27].

Taking ginkgo biloba should always be done in consultation with a physician, especially if you are already prescribed medication.

Who Should Not Take Ginkgo Biloba?

The following people should avoid taking ginkgo altogether:

• Anyone taking blood thinners
• Children
• Pregnant and breastfeeding women
• Epileptic people

FAQ

The effects of ginkgo biloba are almost as rich as its long history! Let’s make it shorter and answer your commonly asked questions:

Is Ginkgo Biloba Safe for Long Term Use?

The answer to this is unclear as further research is needed regarding the long-term effects of taking ginkgo supplements. However, ginkgo biloba is generally considered safe by physicians, unless you are pregnant, epileptic, or taking certain drugs.

Does Ginkgo Biloba Improve Memory?

Yes, it could! Evidence points to improved memory as ginkgo’s key possible benefit.

Can Ginkgo Cause Stroke?

It’s very unlikely, but there’s some anecdotal evidence that people taking ginkgo have also had ischemic attacks [27].

How Long Does Ginkgo Biloba Take to Kick In?

As with most nootropics, you can expect to take the herbal supplement for at least a few weeks before getting the full effects.

Is Ginkgo Biloba Good for the Heart?

Yes, possibly. Improving circulation and dilating blood vessels are effects of ginkgo that are conducive to a healthy heart. It can also reduce blood pressure, another way of lowering strain on the cardiovascular system and heart.

Conclusion

Ginkgo has some wonderful and powerful health benefits, reinforcing the wisdom of traditional Chinese medicine from its ancient past. For its neuro benefits alone, it’s tempting to try it, but just ensure you’re doing it right. 

As discussed in this article, it has strong effects on the body and a few possible interactions. A medical professional should always be consulted before you start taking ginkgo biloba.

References

1. Isah, Tasiu. “Rethinking Ginkgo Biloba L.: Medicinal Uses and Conservation.” Pharmacognosy Reviews, Medknow Publications & Media Pvt Ltd, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4557237/. 
2. Gingko, www.bellarmine.edu/faculty/drobinson/Gingko.asp#:~:text=It%20supposedly%20has%20been%20around,comes%20from%20a%20Japanese%20origin. 
3. Chassagne, François, et al. “Validation of a 16th Century Traditional Chinese Medicine Use of Ginkgo Biloba as a TOPICAL ANTIMICROBIAL.” Frontiers, Frontiers, 1 Jan. 1AD, www.frontiersin.org/articles/10.3389/fmicb.2019.00775/full. 
4. Singh, Sandeep Kumar, et al. “Neuroprotective and Antioxidant Effect of Ginkgo Biloba Extract against Ad and Other Neurological Disorders.” Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics, Springer International Publishing, July 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6694352/. 
5. R;, Field BH;Vadnal. “Ginkgo Biloba and Memory: An Overview.” Nutritional Neuroscience, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/27414695/. 
6. Banin, Renata Mancini, et al. “Ginkgo Biloba Extract (GBE) ATTENUATES Obesity and Anxious/Depressive-like Behaviours Induced BY OVARIECTOMY.” Nature News, Nature Publishing Group, 8 Jan. 2021, www.nature.com/articles/s41598-020-78528-3?utm_source=other&utm_medium=other&utm_content=null&utm_campaign=JRCN_1_LW01_CN_SCIREP_article_paid_XMOL. 
7. Dai, Chun-Xiao, et al. “Role of Ginkgo Biloba Extract as an Adjunctive Treatment of Elderly Patients with Depression and on the Expression of Serum s100b.” Medicine, Wolters Kluwer Health, Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6181482/. 
8. Therapeutic Use of Ginkgo Biloba. opencommons.uconn.edu/cgi/viewcontent.cgi?article=1019&context=som_articles&httpsredir=1&referer=. 
9. Wheatley D. Ginkgo biloba in the treatment of sexual dysfunction due to antidepressant drugs. Hum Psychopharmacol. 1999;14:512–513. [Google Scholar]
10. CS;, Roland PD;Nergård. “[Ginkgo Biloba—Effect, Adverse Events and Drug Interaction].” Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/22562327/. 
11. Nicolaï SP;Gerardu VC;Kruidenier LM;Prins MH;Teijink JA; “From the Cochrane Library: Ginkgo Biloba for Intermittent Claudication.” VASA. Zeitschrift Fur Gefasskrankheiten, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/20464671/. 
12. Wu, Yu-Zhou, et al. “Ginkgo Biloba Extract Improves Coronary Artery Circulation in Patients with Coronary Artery Disease: Contribution of Plasma Nitric Oxide and Endothelin‐1.” Wiley Online Library, John Wiley & Sons, Ltd, 29 Apr. 2008, onlinelibrary.wiley.com/doi/10.1002/ptr.2335. 
13. Meston, Cindy M, et al. “Short- and Long-Term Effects of Ginkgo Biloba Extract on Sexual Dysfunction in Women.” Archives of Sexual Behavior, U.S. National Library of Medicine, Aug. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2863090/. 
14. Ozgoli, Giti, et al. “A Randomized, Placebo-Controlled Trial of Ginkgo Biloba L. in Treatment of Premenstrual Syndrome.” Libertpub.com, The Journal of Alternative and Complementary MedicineVol. 15, No. 8, 13 Aug. 2009. 
15. Kim, Ji Soo, and Hyung Lee. “Posterior Circulation Stroke and Vestibular Syndromes.” Oxford Medicine Online, Oxford University Press, oxfordmedicine.com/view/10.1093/med/9780199608997.001.0001/med-9780199608997-chapter-23. 
16. Cesarani A;Meloni F;Alpini D;Barozzi S;Verderio L;Boscani PF; “Ginkgo Biloba (Egb 761) in the Treatment of Equilibrium Disorders.” Advances in Therapy, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/10345150/. 
17. Sokolova, Larysa, et al. “Treatment of Vertigo: A Randomized, Double-Blind Trial Comparing Efficacy and Safety of Ginkgo Biloba Extract EGB 761 and Betahistine.” International Journal of Otolaryngology, Hindawi Publishing Corporation, 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4099171/. 
18. Quaranta L;Bettelli S;Uva MG;Semeraro F;Turano R;Gandolfo E; “Effect of Ginkgo Biloba Extract on Preexisting Visual Field Damage in Normal Tension Glaucoma.” Ophthalmology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/12578781/. 
19. Zhang, P.F., et al. “Recent Developments in the Mechanism of Ginkgo Biloba Extract in the Treatment of Chronic Obstructive Pulmonary Disease.” 万方数据知识服务平台, May 2017, d.wanfangdata.com.cn/periodical/ChlQZXJpb2RpY2FsQ0hJTmV3UzIwMjEwOTA5Eg96Z3FreXgyMDE3MTUwMjQaCDR0OHk2eXBw. 
20. Chu, Xiao, et al. “A Novel Anti-Inflammatory Role FOR Ginkgolide B in Asthma via Inhibition of THE ERK/MAPK Signaling Pathway.” Molecules (Basel, Switzerland), MDPI, 6 Sept. 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC6264276/. 
21. Tang, Yijun, et al. “The Effect of Ginkgo Biloba Extract on the Expression of Pkcα in the Inflammatory Cells and the Level of Il-5 in Induced Sputum of Asthmatic Patients.” Current Medical Science, Huazhong University of Science and Technology, link.springer.com/article/10.1007/s11596-007-0407-4. 
22. Lejri, Imane, et al. “Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence.” Oxidative Medicine and Cellular Longevity, Hindawi, 12 May 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6535827/. 
23. “Antioxidant Capacity in Ginkgo Biloba.” ResearchGate, www.researchgate.net/publication/223257304_Antioxidant_capacity_in_Ginkgo_biloba. 
24. Sierpina, Victor S, et al. “Ginkgo Biloba.” Complementary and Alternative Medicine, vol. 68, ser. 5, 1 Sept. 2003, pp. 923–928. 5. 
25. “Making Fertility-Friendly Lifestyle Choices.” Harvard Health, 25 Mar. 2017, www.health.harvard.edu/womens-health/making-fertility-friendly-lifestyle-choices#:~:text=Researchers%20at%20Loma%20Linda%20University,and%20reduced%20a%20sperm’s%20viability. 
26. Mei, Nan, et al. “Review of Ginkgo Biloba-Induced Toxicity, from Experimental Studies to Human Case Reports.” Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews, U.S. National Library of Medicine, 2 Jan. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6373469/. 
27. M;, Woroń J;Siwek. “Unwanted Effects of Psychotropic Drug Interactions with Medicinal Products and Diet Supplements Containing Plant Extracts.” Psychiatria Polska, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/30659561/. 

Adderall has brought relief to many people with attention deficit hyperactivity disorder (ADHD). However, in the process, Adderall abuse has also become common. With a reputation for making you smarter, it’s no wonder overworked students are willing to give it a try. Unfortunately, they are probably trading very minor benefits for a slew of serious risks.  

Key Takeaways: Adderall Abuse

• Adderall is a drug used to treat ADHD.
• Adderall is unlikely to improve mental performance if you don’t have ADHD.
• Adderall is an amphetamine and considered a controlled substance.
• It is possible to develop an addiction to Adderall.
• It is possible to overdose on Adderall.
• Adderall abuse can have life-threatening impacts on your health.

What Is Adderall?

Adderall is the brand name of popular prescription drugs used to treat attention deficit hyperactivity disorder (ADHD) [1]. It is also approved to treat narcolepsy. The generic name is mixed amphetamine salts, consisting of both amphetamine and dextroamphetamine. 

Adderall is a central nervous system stimulant, with effects on both voluntary and involuntary functions [2]. It is one of the more common treatment options for ADHD. A range of other drugs are also used to treat the disorder, including Ritalin and Focalin.

As we’ll examine more closely, there is a great deal of illicit Adderall use, usually as a study drug.

How Does Adderall Work?

Someone with ADHD is likely to have lower than average levels of the neurotransmitter dopamine. Like many prescription drugs used for treating ADHD, Adderall increases the production of dopamine.

Dopamine is part of the brain’s reward center and is used to encourage us to do things that help us survive, like find food or build shelter. With healthy levels of dopamine, we’re better motivated to solve problems and therefore find it easier to focus.

What Does Adderall Do to a Normal Person?

It’s important to get the dosage correct when you treat ADHD, as more Adderall isn’t always better. It therefore follows, a neurotypical person taking Adderall may increase dopamine levels to an unhealthy degree. It can have effects on both physical and mental health, including:

• High blood pressure.
• Seizures.
• Trouble sleeping.
• Mood swings.
• Psychotic episodes [2].

Taking Adderall outside a doctor’s direction is a form of prescription drug abuse, with a risk of addiction. Additionally, while Adderall abuse may cause a minor increase in focus, it doesn’t seem to significantly improve memory or cognition.

What Is Adderall Abuse?

Drug abuse is defined as compulsive use of a substance despite negative consequences. Practically speaking, if you’re not treating attention deficit hyperactivity disorder or narcolepsy under a doctor’s care, you’re abusing Adderall.

Students are most likely to abuse Adderall, particularly college students. It’s seen as a study drug, as the increased focus is equated to greater intelligence. However, whatever benefits it has seem to be limited, likely outweighed by the adverse effects experienced when someone abuses Adderall.

Adderall abuse usually leads to tolerance, high doses, and addiction. Some users report snorting Adderall for a quick high. Mixing Adderall with alcohol use is also common.

Statistics of Adderall Abuse in the United States

Methylphenidate, otherwise known as Ritalin, may actually be more commonly abused than Adderall. However, some colleges have reported that more than 25% of their students used prescription stimulants without a prescription [3]. In 2009, it was estimated one in five high school students had used a prescription drug illicitly [4].

Most of the Adderall is supplied through diversion, in which students with legitimate prescriptions give or sell pills to others [5]. As nearly 10% of children have been diagnosed with ADHD, there is a large supply [6]. 

Most people cite cognitive enhancement as the reason for abuse, using Adderall as a smart drug [7]. Substance abuse is often associated with other mental illness, as well. 

Which gender was found to be more likely to misuse Adderall in college?

Male college students

Female college students

Select a choice to reveal the answer

Show hint

Correct! Wrong!

Which gender was found to be more likely to misuse Adderall in college?

14.6% of male college students misuse Adderall and only 8.8% of female college students

Common Signs of Adderall Abuse

Adderall and caffeine are both central nervous system stimulants. Their effects may seem somewhat similar, with both causing things like:

• Restlessness.
• Headache.
• Dizziness.
• Trouble sleeping.

Adderall abuse usually means higher doses than would be taken with a prescription, so signs could include those symptoms and more serious versions.

Among these other Adderall abuse signs, it’s common for those abusing Adderall to also use a variety of other drugs, including alcohol [8].

Side Effects of Adderall Abuse

The side effects of Adderall are generally manageable when taken in prescribed doses. When used at the level of substance abuse, there is a higher risk of adverse effects. Since Adderall is an amphetamine, too much Adderall is similar in effect to that type of drug use.

Short-Term Effects

Even in the short term, the side effects of Adderall abuse can be quite serious. As we’ve mentioned, therapeutic doses can raise a person’s blood pressure. Higher doses put a greater strain on the system so that high blood pressure becomes a heart attack. Effects also include impacts on mental health or even sudden death.

Other short-term side effects of higher doses include:

• Anxiety.
• Twitchiness.
• Aggressiveness.
• Loss of appetite.
• Confusion.
• Dizziness.
• Blurred vision.
• Insomnia.
• Headaches.
• Seizure.
• Mood swings.
• Compulsive behavior.

Long-Term Effects

There have been no long-term studies of Adderall use, either in therapeutic doses or used illicitly. However, prolonged Adderall abuse will be broadly similar to any sort of amphetamine abuse.

One of the chief effects is most likely a build-up of tolerance, in which larger doses are required over time to achieve the desired effects. That leads rapidly to physical dependence and addiction. At that point, ceasing use can lead to dangerous Adderall withdrawal symptoms. 

Abusing amphetamines has also been known to cause mental disorders. Psychotic episodes are most often cited, though amphetamines have also been known to cause schizophrenia-like symptoms [9]. It’s possible that using amphetamines at a younger age also makes you vulnerable to bipolar disorder [10].

The damage to the cardiovascular system also increases over time. Increased blood pressure over prolonged periods makes cardiovascular disease more likely. Irregular heartbeats and a weakened heart are also possible.

How Does Adderall Affect the Brain?

In addition to producing dopamine, Adderall also prompts the brain to make several other neurotransmitters, including adrenaline, norepinephrine, and serotonin [11].

Dopamine gets the spotlight because it’s useful in treating a variety of illnesses, producing a feeling of wellness. It’s also the driving factor in most substance addiction, as users chase that pleasurable sensation. When dopamine levels drop, as the drug wears off or the user quits using, Adderall withdrawal symptoms occur.

Adderall and Depression

While Adderall is not approved for use in treating depression or anxiety, many people with ADHD also suffer from those conditions [12]. Stimulant drugs that produce dopamine are sometimes used to treat depression, so Adderall may have some benefits there.

However, that is also likely to be a reason Adderall is abused to a dangerous degree. Addicts often suffer from depression and use drugs to self-medicate. Unfortunately, amphetamines have also been known to cause depressive symptoms, leading to a dangerous downward spiral [13].

Personality Changes While Taking Adderall

Adderall can cause changes in mood and behavior, or worsen already existing issues. Amphetamines generally can cause extreme mood swings. Increases in anxiety can also lead to panic attacks and paranoia. Adderall may also cause aggressiveness.

More serious mental health problems may also be caused. Psychosis and mania are the most commonly cited dangers. Using Adderall may also cause serotonin syndrome, causing hallucinations, agitation, and delusions.

Physical Effects of Adderall Addiction

At this point, it should be obvious that Adderall abuse and addiction result in some serious health risks. We’ve looked at some of the immediate physical and mental side effects of using Adderall. Some physical effects already discussed include:

• Weight loss.
• Increase blood pressure.
• Higher risk of cardiovascular disease.
• Increased risk of heart attack.
• Twitchiness or tremors.
• Seizures.

In younger people, there is a possibility Adderall’s properties can suppress growth. Additionally, it may cause damage to blood vessels or lead to a rare condition called Raynaud’s phenomenon [1]. Other serious physical effects could include:

• Serious skin rash.
• Necrosis of the skin.
• Alopecia.
• Dissolution of muscle tissue [14].
• Increased body temperature.

Recognizing the Signs of Adderall Addiction

The range of potential adverse effects may make prescription stimulant use seem terrifying. However, most of them only appear in rare or particularly severe cases. It’s much more difficult to spot Adderall drug addiction in earlier stages. Despite that, there are several signs you can look for.

Physical signs include things like:

• Sudden weight loss.
• Tiredness and lethargy.
• Sleep problems.
• Twitchiness.

Behavioral signs include things like:

• Dramatic mood swings.
• Manic episodes.
• Aggressiveness.
• Repetitive behaviors.

In extreme cases, users may experience formication hallucinations, characterized by itchiness without apparent cause. Paranoia and bizarre delusions are also possible. Additionally, stimulant drug use masks the effects of alcohol, making alcohol poisoning more likely [15].

Drug addiction can also make itself known in other aspects of life, such as poor personal hygiene or losing contact with friends.

Intervention and Next Step Options

It is certainly possible to overcome addiction to Adderall. However, it may require professional addiction treatment or a stay at a treatment center. Withdrawal from amphetamines can cause some serious health issues. Additionally, if you attempt to take a higher dose after going through withdrawal, your odds of overdosing are much higher.

Unfortunately, there are no drugs that would make Adderall addiction treatment easier [16]. There are a number of behavioral options that might help, however. More information can be found on the Substance Abuse and Mental Health Services Administration website.

Adderall Alternatives: Nootropics

The most commonly given reason for Adderall abuse is cognitive enhancement. In simple terms, it has a reputation for making you smarter. Adderall probably doesn’t live up to that reputation. 

Drugs meant to make you smarter are called nootropics. While many are so potent as to be dangerous, there are some supplements that are safer and cheaper. They may not rev your mental motor as much as stimulant medication, but they also are less likely to grind your gears.

Benefits of Nootropics

Most nootropics work along broadly similar lines as Adderall. Dopamine production is encouraged, which activates the reward centers of the brain. That provides some mental motivation, providing neurochemical resources for solving problems. As a result, nootropics for motivation are often the most effective option.

Nootropic supplements will also often include ingredients that have neuroprotective properties. Rather than providing a mental boost at the cost of brain health, nootropic supplements may actually leave your brain healthier.

Types of Nootropics

Legal, safe nootropic options are usually supplements that you take on a regular basis. They provide a general, consistent boost in focus, concentration, and memory, as well as supporting good brain health.

These are a couple of our favorite options, containing safe and useful ingredients.

Mind Lab Pro

Mind Lab Pro uses an array of ingredients to help you focus, as well as providing a range of other benefits. In particular, Mind Lab Pro relies on citicoline to serve as an Adderall alternative, mildly upping dopamine production [17]. 

Additionally, all their products contain sustainable ingredients and are shipped in environmentally responsible packaging. Find out more in our detailed Mind Lab Pro review.

Performance Lab Nootropic

Similar in many ways to Mind Lab Pro’s offering, Performance Lab Mind also contains citicoline as a way of increasing dopamine, and therefore motivation. Other ingredients prevent oxidative damage or provide raw materials for making more dopamine [18][19].

If that sounds interesting, take a closer look at our Performance Lab Pro review.

FAQ

If you’re less interested in brain chemistry and more interested in simple answers, this is the section for you.

What Are Adderall Addiction Symptoms?

Addiction to Adderall will have many of the same symptoms as any sort of addiction, including behavior changes and a narrowing of interest. Symptoms specific to Adderall can include:

• Dropping weight suddenly.
• Sleep problems.
• Twitchiness.
• Mood swings.
• Repetitive behaviors.
• Aggressiveness.

What Happens If You Take Adderall Without ADHD?

You may find that your ability to focus improves slightly. However, you’re also likely to:

• Become more anxious.
• Have difficulty sitting still.
• Become dizzy or confused.
• Have an increased heart rate.
• Become nauseous.
• Develop headaches.

Can I Get Better Grades on Adderall?

If you do, you might want to consider being tested for ADHD. Otherwise, Adderall is as likely to be a hindrance as a help in school work. In people without ADHD, Adderall causes a range of negative effects that are likely to interfere with doing well at school. 

Is It Possible to Overdose on Adderall?

It is absolutely possible to have a life-threatening overdose on Adderall. As an amphetamine, Adderall is a potent drug that can strongly affect your system in many ways. Additionally, one of the potential side effects is sudden death.

Conclusion

Under the direction of a doctor, Adderall can be of benefit to some people. However, abusing Adderall is gambling with your health with no real chance of winning. After all, if the pill really made you smarter, you’d probably be wise enough to stop taking it.

References:

1. “Adderall CII.” Access Data, Federal Drug Administration, www.accessdata.fda.gov/drugsatfda_docs/label/2017/011522s043lbl.pdf.
2. Shoar, Nazila Sharbaf. “Dextroamphetamine-Amphetamine.” StatPearls [Internet]., U.S. National Library of Medicine, 5 June 2021, https://www.ncbi.nlm.nih.gov/books/NBK507808/. 
3. Weyandt, Lisa L., et al. “Neurocognitive, Autonomic, and Mood Effects of Adderall: A Pilot Study of Healthy College Students.” MDPI, Multidisciplinary Digital Publishing Institute, 27 June 2018, https://www.mdpi.com/2226-4787/6/3/58/htm.
4. “Media Statement.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 3 Jan. 2010, https://www.cdc.gov/media/pressrel/2010/s100603.htm.
5. Darredeau, Christine, et al. “Patterns and Predictors of Medication Compliance, Diversion, and Misuse in Adult Prescribed Methylphenidate Users.” Human Psychopharmacology, U.S. National Library of Medicine, 22 Dec. 2007, https://pubmed.ncbi.nlm.nih.gov/17910020/.
6. “Data and Statistics about ADHD.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 23 Sept. 2021, https://www.cdc.gov/ncbddd/adhd/data.html.
7. Sussman, Steve, et al. “Misuse of ‘Study Drugs:” Prevalence, Consequences, and Implications for Policy.” Substance Abuse Treatment, Prevention, and Policy, BioMed Central, 9 June 2006, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1524735/.
8. Meisner, Jessica R, et al. “Extended Release Stimulant Medication Misuse with Alcohol Co-Administration.” Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal De L’Academie Canadienne De Psychiatrie De L’enfant Et De L’adolescent, Canadian Academy of Child and Adolescent Psychiatry, Nov. 2008, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583913/.
9. Lakhan, Shaheen E, and Annette Kirchgessner. “Prescription Stimulants in Individuals with and without Attention Deficit Hyperactivity Disorder: Misuse, Cognitive Impact, and Adverse Effects.” Brain and Behavior, Blackwell Publishing Inc, Sept. 2012, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489818/#b37.
10. DelBello, Melissa P, et al. “Prior Stimulant Treatment in Adolescents with Bipolar Disorder: Association with Age at Onset.” Wiley Online Library, John Wiley & Sons, Ltd, 24 Jan. 2002, https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1399-5618.2001.030201.x.
11. Vasan, Sarayu, and Garth J Olango. “Amphetamine Toxicity.” Europe PMC, 10 July 2021, https://europepmc.org/article/NBK/nbk470276.
12. Coughlin, Catherine G, et al. “Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder.” Journal of Child and Adolescent Psychopharmacology, Mary Ann Liebert, Inc., Oct. 2015, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617411/.
13. Leventhal, Adam M, et al. “Anhedonia Associated with Stimulant Use and Dependence in a Population of American Adults.” American Psychological Association, American Psychological Association, 2010, https://psycnet.apa.org/record/2010-26426-012.
14. Torres, Patrick A, et al. “Rhabdomyolysis: Pathogenesis, Diagnosis, and Treatment.” The Ochsner Journal, The Academic Division of Ochsner Clinic Foundation, 2015, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365849/.
15. “Commonly Used Drugs Charts.” National Institute on Drug Abuse, 20 Aug. 2021, https://www.drugabuse.gov/drug-topics/commonly-used-drugs-charts#prescription-stimulants.
16. Shoptaw, Steven J, et al. “Treatment for Amphetamine Withdrawal.” The Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd, 15 Apr. 2009, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138250/.
17. Jasielski, Patryk, et al. “Application of Citicoline in Neurological Disorders: A Systematic Review.” MDPI, Multidisciplinary Digital Publishing Institute, 12 Oct. 2020, https://www.mdpi.com/2072-6643/12/10/3113/htm.
18. Rafnsson, Snorri Bjorn, et al. “Antioxidant Nutrients and Age-Related Cognitive Decline: A Systematic Review of Population-Based Cohort Studies.” European Journal of Nutrition, U.S. National Library of Medicine, 7 June 2013, https://pubmed.ncbi.nlm.nih.gov/23744025/.
19. “Tyrosine.” Tyrosine – Health Encyclopedia – University of Rochester Medical Center, https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=19&contentid=Tyrosine. 

Perhaps you were prescribed Adderall and can’t stand the side effects anymore. Or, maybe you want to clear your head and get motivated without the risks of illegal drug use. 

Natural nootropic supplements are a safer way to boost your brainpower when you’re dealing with a poor attention span or lack of motivation. Some ingredients act as stimulants by increasing neurotransmitters; others protect and regulate brain cells (neurons). 

Let’s look at some of the best nootropics that can act as over-the-counter Adderall.

Quick View

• Best Overall – Mind Lab Pro
• Best for Key Ingredients – Performance Lab Mind 
• Best for Fast Results – NooCube 
• Best for Brain Nutrition – Qualia Mind
• Best Circulation Boost – BrainPill

Best Overall – Mind Lab Pro 

Quick Verdict 

Best Overall – Mind Lab Pro 

Mind Lab Pro is the best overall when it comes to nootropics, thanks to its all-around cognitive benefits. As our Mind Lab Pro review explains, this natural Adderall alternative contains 11 ingredients to enhance the production of dopamine and other neurotransmitters, boost brain regeneration, and protect the neurons you already have through antioxidant support. 

Adderall vs Over the Counter Adderall

Adderall is a prescription pharmaceutical used to manage attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Adderall is not sold over the counter, as its side effect profile makes it unsafe. Some people buy Adderall or similar stimulants illegally as “smart drugs”, even if they have no ADHD symptoms [1]. 

Among college students, who is more likely to misuse Adderall?

Women

Men

Click on an answer to reveal what surveys found

Show hint

Correct! Wrong!

Among college students, who is more likely to misuse Adderall?

It was found that among college students, men were more likely to misuse Adderall

What Is Adderall?

Adderall is a legal amphetamine, containing both D- and L-amphetamine. In chemistry terms, D- and L- versions of molecules are mirror images of each other and have different effects as a result. While D-amphetamine is more potent, L-amphetamine lasts longer in the body [1]. 

Adderall works by increasing your brain’s levels of dopamine and noradrenaline to help you stay focused and motivated. Dopamine increases the amount of effort you’re willing to make in order to achieve something. Even if you enjoy something, low dopamine can wipe out your motivation to do it [2]. 

Restoring levels of the neurotransmitter can therefore leave you feeling much better, as you’re able to work towards your goals more effectively. 

What Is Over the Counter Adderall?

As a prescription-only drug, you can’t buy Adderall over the counter. The U.S. Food and Drug Administration (FDA) also classifies Adderall as a Schedule II Controlled Substance. This is because of its addictive potential and presence on the black market as a study drug [1]. 

What’s the Closest Thing to Adderall Over the Counter?

The closest and safest thing to buying Adderall over the counter is a class of supplements known as nootropics. These are natural Adderall alternatives with more positive side effects, such as an increase in brain regeneration rates or antioxidant support, and fewer (if any) negative side effects. The effect of nootropics on cognitive functions is, overall, milder yet broader. 

What Are Nootropics?

Nootropics are nutrients, herbal remedies, and some pharmaceuticals that are chosen or designed to boost brain function. Most earn a place in this category by increasing the levels of neurotransmitters, including dopamine, noradrenaline, and serotonin [3]. 

How Do Nootropics Work?

Some ingredients in nootropic supplements have other benefits, too. These include antioxidant and anti-inflammatory support, which protects neurons from the everyday damage that can build up over time. Others increase the rate of natural brain regeneration, boost blood flow, increase cellular energy production, and balance brain waves. 

What Are the Natural Ingredients in Nootropics?

Some of the best ingredients in nootropics include:

• Citicoline.
• Rhodiola rosea.
• L-tyrosine.
• Ginkgo biloba.
• Bacopa monnieri.
• Phosphatidylserine.
• Coenzyme Q10.
• Vitamin B12.

Citicoline

Citicoline is a safe supplemental version of choline, used to make the neurotransmitter acetylcholine. Clinical studies show improved performance on cognitive health tests, in both accuracy and reaction time, as well as brain wave patterns that indicate better focus. These same brainwave patterns are used to differentiate between people with and without ADHD [4]. 

Rhodiola Rosea

Rhodiola rosea is a herbal medicine gaining popularity in the West as part of nootropics for energy. The natural substance increases levels of the neurotransmitters dopamine, serotonin, noradrenaline, and acetylcholine while reducing the stress hormone cortisol. In human clinical studies, rhodiola shows the ability to improve concentration, mental energy, and mood [5]. 

L-Tyrosine

L-tyrosine is an amino acid used to produce dopamine and noradrenaline, making it a direct natural Adderall alternative. Most clinical trials show beneficial effects of tyrosine on cognition, although some only demonstrate short-term improvements that are not sustained after supplementation ends [6]. 

Ginkgo Biloba

Ginkgo biloba is a popular inclusion in nootropics for memory. It can improve blood flow to the brain, as seen on imaging studies during both short-term (four weeks) and long-term (eight months) supplementation. Healthy younger volunteers and those with age-related cognitive decline have shown improvements in focus and memory retention.

As for ADHD, ginkgo may be a useful ingredient in natural Adderall alternatives. Two clinical studies have shown improvements in symptoms, alongside better circulation to the brain and increased levels of neurotransmitters including noradrenaline [7]. 

Bacopa Monnieri

Bacopa monnieri can boost focus alongside cognitive processing speed. Its effects on the brain include an increase in dopamine, acetylcholine, and GABA, along with decreased cortisol. This is the main stress hormone that impairs cognitive function. 

A standardized extract of Bacopa monnieri has been shown to relieve some symptoms of ADHD, possibly demonstrating itself to be an Adderall alternative. Inattention, poor self-control, impulsivity, and restlessness all were relieved by Bacopa monnieri extract [7]. 

Phosphatidylserine

Phosphatidylserine has shown benefits for brain functioning, specifically in cases of ADHD. Short-term memory, impulsivity, and inattention all improved in one study of phosphatidylserine, with no negative side effects. It increases the brain chemicals dopamine, glutamate, and acetylcholine, all essential for cognitive performance [8].

Additionally, phosphatidylserine is one of the long-term cognitive enhancers, as it improves brain regeneration. Research shows that it assists nerve growth factor transport through neurons, supporting their repair and growth [9]. 

Coenzyme Q10

Coenzyme Q10 is essential for cellular energy production and acts as an antioxidant in the mitochondria. These are the energy-producing centers of the cell and are perhaps exposed to more oxidative stress than any other part of the body. What’s more, coenzyme Q10 could even support the production of new neurons. 

Much of the age-related decline in cognitive function is caused by impaired brain regeneration, which falls by 80% from young adulthood to older age. It’s made even worse by the destructive plaque seen in Alzheimer’s disease, too. Coenzyme Q10 may rescue neural stem cells in this situation, by acting on genes important for cellular survival [10]. 

Vitamin B12

Vitamin B12 supports neurotransmitter production by aiding homocysteine metabolism, which prevents inflammation and oxidative stress. Even better, vitamin B12 assists in myelin synthesis. This is the fatty sheath that protects brain and nerve cells and allows them to efficiently communicate [11]. 

The Five Best Over-the-Counter Adderall Alternatives

With so many supplements out to boost brain performance, we thought we’d review five of the best brain supplements.

Mind Lab Pro – Best Overall

Pros: 

• All-round nootropic support for cognitive enhancement.
• Ingredients demonstrated efficacy in healthy and chronic illness states.
• Includes lion’s mane extract to enhance brain regeneration.
• No “single task” ingredients.
• No proprietary formulas; complete transparency.

Cons: 

• Cost is over $4 per daily dose.
• May contain subtherapeutic doses of some ingredients.

Mind Lab Pro leaves no stone unturned. All ingredients have multiple functions; for example, ginkgo biloba provides cellular protection and boosts blood flow, while L-theanine is able to modulate brain waves and support neurotransmitter production. 

This list of benefits makes Mind Lab Pro one of the best Adderall alternatives, particularly if you are looking to boost your overall performance. As L-theanine is a calming ingredient through increased GABA production, you can also enjoy a more relaxed mood and improved sleep [12]. Adderall, on the other hand, can cause insomnia and irritability [1]. 

Bottom Line: 

Mind Lab Pro is the best Adderall alternative to improve brain health and enhance cognitive function. With support for brain regeneration, stress-relieving properties, and more, the side effects of Adderall are replaced with side benefits. 

Performance Lab Mind – Best for Key Ingredients

Pros: 

• Lower cost per dose, at a little over $2 per day.
• Powerful antioxidant support with maritime pine bark extract.
• Dopamine and noradrenaline support.
• Citicoline for brain wave regulation.

Cons: 

• No references provided for science behind ingredients.
• No explanation for superiority of Ajipure tyrosine formulation. 

A more streamlined supplement with only four ingredients, Performance Lab Mind is still one of the best natural Adderall alternatives. Including the amino acid tyrosine to boost dopamine and noradrenaline production and support for neuroregeneration and antioxidant status, it is our second pick. Learn more in this Performance Lab review. 

Protection through antioxidant support and the promotion of brain cell regeneration can make Performance Lab Mind your go-to OTC Adderall if you’re coming off the drug. Adderall withdrawal, possibly including missing or taking your next dose a little later, increases levels of the stress hormone, cortisol [13]. This damages the brain cells and impairs cell regeneration [14].

Bottom Line:

With antioxidant power, stress relief, and pro-repair effects accompanying neurotransmitter support, Performance Lab Mind may help you recover from the effects of long-term Adderall use. 

NooCube – Best for Fast Results 

Pros: 

• Ingredients have shown clinical benefits in healthy volunteers and those with Alzheimer’s disease.
• Broad-spectrum cognitive benefits through neurotransmitter stimulation.
• Calming effect of oat straw and L-theanine.
• Powerful antioxidant effect of cat’s claw extract.

Cons: 

• Contains gluten from oat straw.
• No direct brain regeneration support.

With some of its neurotransmitter-boosting benefits taking effect in hours, NooCube may be one of the closest natural Adderall replacements. For example, green oat extract has shown to improve performance speed, executive function, and word recall after just one dose in people with mild age-related cognitive decline [15]. 

Bottom Line: 

If you’re looking for speedy relief from brain fog, you may have come to the right place with NooCube—unless you’re gluten intolerant. 

Qualia Mind – Best for Brain Nutrition 

Pros: 

• Broad-spectrum cellular energy production support with B vitamins and more.
• Range of neurotransmitters supported, including several ingredients for acetylcholine.
• Powerful antioxidant ingredients for cellular protection.

Cons: 

• Higher doses required to reach therapeutic levels for the large number of ingredients.

Qualia Mind aims to do everything, with its longer ingredients list and higher dosage. Individual ingredients often have more than one benefit each, including the powerful antioxidant pyrroloquinoline quinone (PQQ). Not only is it stronger than vitamin C, but it may also boost brain regeneration via nerve growth factor and reduce cortisol [16]. 

It is this cortisol reduction that makes Qualia Mind another potentially helpful Adderall alternative, especially if you are coming off the drug and wishing to increase your mental and physical energy. 

Bottom Line: 

Qualia Mind takes acting as a brain food supplement to the next level with its comprehensive ingredient list. 

BrainPill – Best Circulation Boost

Pros: 

• Essential B vitamins involved in neurotransmitter and cellular energy production.
• Support with mental clarity and memory retention with acetylcholine-boosters.
• Anti-inflammatory effects of DHA and antioxidants in ginkgo.

Cons: 

• Contains titanium dioxide, which has a questionable safety profile [17]. 
• Little transparency available with scientific evidence. 

Brain Pill contains many of the natural herbs, essential vitamins, and other nutrients commonly found in natural alternatives to Adderall. Vinpocetine, however, is a unique ingredient of Brain Pill, which has demonstrated the ability to enhance circulation and cellular energy production in neurons. This includes clinical studies on post-stroke patients, where circulation has been interrupted [18]. 

Bottom Line:

Brain Pill shines in its broad support for neurotransmitter production and circulation. However, poor ingredient transparency and the inclusion of titanium dioxide knock off a few points. 

Other Adderall Alternatives

Certain diet and lifestyle changes, energy supplements, and even prescription medication can act as good Adderall alternatives, alone or alongside nootropic supplements. 

Dietary and Lifestyle Changes

Certain nutrients boost brain health over time. For example, omega-3 fatty acids found in oily fish can significantly improve ADHD-related symptoms, such as poor attention span and impulsivity. Omega-3 fatty acids benefit cell growth and signaling, as well as dopamine and serotonin production [7]. 

Overall, a Mediterranean dietary pattern may improve mental cognition and is the best way to prevent cognitive impairment. A diet rich in whole grains, legumes, fruit, vegetables, fish, nuts, and herbs can give essential antioxidant and neurotransmitter support. It is not powerful enough to be a natural alternative to Adderall alone, so is best used alongside natural nootropics [3]. 

Energy Drinks

Some energy drinks contain B vitamins for neurotransmitter production, alongside other energy boosters and caffeine for a short-term boost in mental performance. However, choose these with caution, as many contain high levels of sugar, too. 

Prescription Medication

Methylphenidate (Ritalin) is a non-amphetamine ADHD medication that slows the removal of dopamine and noradrenaline, much like how SSRIs work with serotonin in depression. Peak levels of Ritalin appear in the blood from one to three hours, so it does not last as long as Adderall [19]. 

This may mean you can control the side effects more easily, by timing the dose to when you need it most. 

FAQ

Here is some more information on OTC Adderall and natural alternatives.

Can You Get Over the Counter Adderall?

Adderall is a prescription-only drug and categorized as a Schedule II Controlled Substance. It is therefore illegal to sell over the counter as a smart drug. As an alternative, nootropic brain supplements like Mind Lab Pro are available to purchase without a prescription.

What Medication Is Closest to Adderall?

Methylphenidate (Ritalin) is one of the best Adderall alternatives when it comes to pharmaceutical drugs. Like Adderall, it increases levels of dopamine and noradrenaline. It is one of the shorter-acting smart drugs, with its levels peaking in the body at one to three hours [19]. 

Can You Get Adderall Without a Doctor?

As you require a doctor to write a prescription first, it is not possible to get Adderall without a doctor, unless your prescription includes refills. Some people illegally purchase Adderall as a smart drug through others who can get a prescription or obtain it through other means. This can be extremely dangerous, as you may have a serious adverse reaction but have no access to medical support.

Can You Buy Over the Counter Adderall in Walmart? 

You cannot buy Adderall over the counter in Walmart, because it is prescription-only. 

Conclusion

There are many OTC Adderall alternatives on the market today, aimed at stacking a range of ingredients to maximize cognitive performance and overall health benefits. Mind Lab Pro, followed by Performance Lab, NooCube, Qualia Mind, and Brain Pill, are standout natural supplements that can be used as a smart drug.

Their comprehensive formulations don’t stop at the support for dopamine and noradrenaline they need to act as alternatives to Adderall. They also add in brain regeneration boosts, cellular protection, improved brain energy production, and regulation of brain function. 

References:

1. U.S. Food and Drug Administration. “Adderall.” (2017) https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/011522s043lbl.pdf
2. Berke, Joshua D. “What does dopamine mean?.” Nature neuroscience vol. 21,6 (2018): 787-793. doi:10.1038/s41593-018-0152-y 
3. Onaolapo, Adejoke Yetunde et al. “Brain Ageing, Cognition and Diet: A Review of the Emerging Roles of Food-Based Nootropics in Mitigating Age-related Memory Decline.” Current aging science vol. 12,1 (2019): 2-14. doi:10.2174/1874609812666190311160754 
4. Bruce, Steven E et al. “Improvements in concentration, working memory and sustained attention following consumption of a natural citicoline-caffeine beverage.” International journal of food sciences and nutrition vol. 65,8 (2014): 1003-7. doi:10.3109/09637486.2014.940286 
5. Olsson, Erik M et al. “A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.” Planta medica vol. 75,2 (2009): 105-12. doi:10.1055/s-0028-1088346 
6. Jongkees, Bryant J et al. “Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review.” Journal of psychiatric research vol. 70 (2015): 50-7. doi:10.1016/j.jpsychires.2015.08.014 
7. Ahn, James et al. “Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy.” Neural plasticity vol. 2016 (2016): 1320423. doi:10.1155/2016/1320423 
8. Hirayama, S et al. “The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial.” Journal of human nutrition and dietetics : the official journal of the British Dietetic Association vol. 27 Suppl 2 (2014): 284-91. doi:10.1111/jhn.12090 
9. Naftelberg, Shiran et al. “Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.” Neural regeneration research vol. 12,4 (2017): 534-537. doi:10.4103/1673-5374.205082 
10. Choi, Hojin et al. “Coenzyme Q10 restores amyloid beta-inhibited proliferation of neural stem cells by activating the PI3K pathway.” Stem cells and development vol. 22,15 (2013): 2112-20. doi:10.1089/scd.2012.0604 
11. Calderón-Ospina, Carlos Alberto, and Mauricio Orlando Nava-Mesa. “B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin.” CNS neuroscience & therapeutics vol. 26,1 (2020): 5-13. doi:10.1111/cns.13207 
12. Park, Sang-Ki et al. “A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study.” Journal of medicinal food vol. 14,4 (2011): 334-43. doi:10.1089/jmf.2009.1374 
13. Bray, Brenna, et al. “Amphetamine withdrawal differentially affects hippocampal and peripheral corticosterone levels in response to stress.” Brain Research, 1644, (2016): 278–287. doi:10.1016/j.brainres.2016.05.030 
14. de Souza-Talarico, Juliana Nery et al. “Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging.” Dementia & neuropsychologia vol. 5,1 (2011): 8-16. doi:10.1590/S1980-57642011DN05010003 
15. Kennedy, David O et al. “Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial.” Nutritional neuroscience vol. 20,2 (2017): 135-151. doi:10.1080/1028415X.2015.1101304 
16. Akagawa, Mitsugu et al. “Recent progress in studies on the health benefits of pyrroloquinoline quinone.” Bioscience, biotechnology, and biochemistry vol. 80,1 (2016): 13-22. doi:10.1080/09168451.2015.1062715 
17. Winkler, Hans Christian et al. “Critical review of the safety assessment of titanium dioxide additives in food.” Journal of nanobiotechnology vol. 16,1 51. 1 Jun. 2018, doi:10.1186/s12951-018-0376-8 
18. Zhang, Yi-Shuai et al. “An update on vinpocetine: New discoveries and clinical implications.” European journal of pharmacology vol. 819 (2018): 30-34. doi:10.1016/j.ejphar.2017.11.041 
19. Shellenberg, Thomas P et al. “An update on the clinical pharmacology of methylphenidate: therapeutic efficacy, abuse potential and future considerations.” Expert review of clinical pharmacology vol. 13,8 (2020): 825-833. doi:10.1080/17512433.2020.1796636

L-theanine has fantastic healing properties, according to peer-reviewed studies. They range from detox to better sleep quality, weight loss and even support cancer treatment. Although naturally occurring in tea, the functional food additive should also be taken with some precaution in supplement form.

This article is a simple guide to the key effects and uses of the compound, with recommendations to supplements and how best to use them.

Key Takeaways: L-Theanine Weight Loss and Memory Boost

• L-theanine is a unique amino acid compound found in tea plants.
• Its health benefits have been recognized since ancient times in Japan and China.
• Scientific evidence shows that it can prevent and improve certain diseases or health problems, as well as improve cognitive function and reduce stress.
• L-theanine is generally recognized as safe but should not be taken by pregnant or lactating women or children.
• There are a variety of l-theanine supplements available.

L-Theanine: Overview

See below for a straightforward summary of what L-theanine is and how it could be effective in weight loss.

What Is It?

L-theanine is a naturally occurring compound from the camellia sinensis plant, or the tea plant. It is commonly found in green and black tea, as well as some mushrooms. 

Specifically, it is an amino acid, made of essential elements that combine to form proteins. They are highly important for many of the body’s vital functions.

Amino acids are not produced in the body and have to be consumed through food, drinks, or an L-theanine supplement.

How Does It Work?

L-theanine has many qualities that may be highly advantageous to health. The tumor reducing, anti-inflammatory, antimicrobial, and antioxidant properties found in tea, due to its L-theanine content, are key to these benefits. 

Inflammation is an outcome of many health problems, such as diabetes, high blood pressure, cancer, and arthritis. Therefore, green tea’s generalized anti-inflammatory effects may have benefits for all of these conditions.

The antioxidant properties of green tea include the ability to limit the number of free radicals in the body and increase the activity of antioxidant enzymes, helping to regulate cell development. This gives a detoxing effect and supports disease prevention.

For these reasons, L-theanine in green tea is also beneficial for cardiovascular diseases, obesity, and oral health problems [1]. 

L-theanine impacts neurological functioning because it can cross the blood-brain barrier and regulate hormones in the brain, positively impacting brain waves. This influences the central nervous system, reducing subjective stress, increasing subjective alertness, and enhancing mental focus [2]. 

Does L-Theanine Help With Weight Loss?

L-theanine is known for its anti-obesity effects, especially when combined with other ingredients. Green tea catechins and caffeine, which are also consumed when drinking green tea, are believed to enhance energy and boost metabolism—qualities generally associated with weight loss. However, peer-reviewed studies suggest this is not the main reason tea may be effective in weight loss [3].

In fact, green tea can alter digestive enzymes to reduce fat accumulation, which may be why it stops body weight increase. It can also decrease blood pressure and lowers cholesterol [1].

Dieticians suggest that green tea can also support weight loss for a more simple reason—drinking a cup of hot tea before a meal and staying hydrated can act as an appetite suppressant and lead to healthier food choices. If weight loss is important to you, talk with your dietician about the benefits of green tea.

L-theanine causes the savory flavor in green tea, which can reduce your appetite and essentially help you lose weight. The compound is also quite a powerful stress reducer and sleep aid, which are factors that contribute to weight loss as well [4].

L-Theanine Uses

L-theanine has been shown to have many other benefits to health, primarily:

• Boosting cognitive function.
• Relieving stress and anxiety.
• Improving immunity.
• Increasing focus.
• Enhancing treatment for cancer patients.
• Possibly reducing the risk of Alzheimer’s disease.

Boosts Cognitive Function

The calming effects of L-theanine are said to improve brain function. In a double-blind placebo-controlled clinical trial of older people supplemented with L-theanine for 12 weeks, memory and reaction time improved during the period of the clinical trial [5].

This is likely due to the effect that L-theanine has on brain waves. Although it is thought that caffeine improves cognitive performance, research suggests that caffeine intake  actually reduces memory capacity. It is the mood-enhancing effect of L-theanine, its impact on objective sleep quality and wakefulness, that is responsible for the difference in executive function.

Relieves Stress and Anxiety 

Evidence shows the de-stressing effects of low caffeinated green tea consumption. Tests with animals where physical and psychological stresses were created then stress-related symptoms treated with L-theanine have shown favorable physiological stress responses [6].

This is because L-theanine has a direct effect on the brain. In another placebo-controlled clinical trial, L-theanine was shown to significantly increase alpha brain waves, which promotes alert relaxation without making you sleepy. This is also known as subjective wakefulness [7].

Stress caused by schizophrenia and schizoaffective disorder has also been examined in its relationship with L-theanine. 

In a double-blind placebo-controlled trial, 60 schizoaffective disorder patients participated in an 8-week trial. They received 400mg per day of L-theanine with their usual drug administration. Compared with the placebo group, the L-theanine group was associated with reducing anxiety [8].

According to a review of the evidence by academic research institutions, anxiety symptoms caused by all mental health problems can be helped safely with 200–400mg of L-theanine per day. This is thanks to its stimulation of alpha brain waves and effect on the central nervous system to promote relaxation [9].

Does L-Theanine have an effect on depression?

Yes, it can make depression worse

Yes, it can reduce depression

No, it has no effect on depression

Choose the option you think is right to reveal what studies have found

Show hint

Correct! Wrong!

Does L-Theanine have an effect on depression?

L-Theanine showed to improve symptoms of depression

May Improve Immunity

Green tea has been shown to support the immune system in randomized controlled clinical trials.

In a medical exploration with rats, L-theanine’s results on immune function were positive [10].

This is because of L-theanine’s effect on the brain, including in the pituitary gland, impacting hormones. It also helps the body produce anti-inflammatory cytokines, a type of protein that can reduce inflammation caused by illness [11].

Increases Focus

A peer-reviewed study about L-theanine and caffeine stimulation to assess the possible treatment of attention deficit hyperactivity disorder showed that L-theanine boosts focus, but caffeine does not. Though it is believed caffeine improves cognitive performance, it has a negative impact on memory and healthy sleep. 

Attention deficit hyperactivity disorder is characterized by a lack of attention and ability to focus, as well as impulsive behavior. Alpha activity is known to play an essential role in improving attention span and cognitive performance [12].

The effects of L-theanine, even at levels that are realistic to normal intake from drinking tea daily, increases subjective alertness and contributes to a naturally enhanced state of focus [13].

May Enhance Cancer Treatment 

Drinking tea has been shown to support the treatment of cancer alongside medical interventions. 

In an extensive study of 254 patients diagnosed with cancer, the group who increased their green tea consumption showed a more significant improvement than those who did not. Therefore, it was conclusive in the study that theanine enhances recovery as it increases cancer patients’ survival time due to its anticarcinogenic effects [14].

There are mixed views on the extent to which green tea can prevent cancer or support in its recovery. Further scientific research is available about how L-theanine compounds can affect the behavior of cells and prevent cancer. It is seen as a dietary supplement for general health benefits, though, as opposed to a cure [15].

May Reduce Risk of Alzheimer’s Disease 

Alzeheimer’s is an inherited neurodegenerative condition whereby brain function, reactions, and memory decrease in old age to a point that severely interferes with daily life.

Research on how to prevent the condition or reduce the extent of deterioration it causes is becoming more prominent, and L-theanine has been tested for this reason.

In a 2018 review of tea drinking evidence relevant to Alezheimer’s, L-theanine is not yet a proven cure. However, with more clinical trials making this link, it could prove useful in the fight against Alzheimer’s disease [16].

L-Theanine Side Effects

L-theanine is not known to have any significant side effects, although there are a few points to consider if you are thinking of taking L-theanine.

Precautions and Warnings

The FDA classification of L-theanine is “generally recognized as safe,” which means an L-theanine supplement has no health risk if used as recommended [17].

However, there is limited research to show the effect that L-theanine may have on women who are pregnant or breastfeeding. Therefore, it is not recommended for use during pregnancy or lactation. 

Animal studies whereby a higher dosage of L-theanine is administered have been associated with some liver damage due to toxicity—a general side effect of taking too much of a substance [18].

Science suggests daily doses ranging from 200 to 400 mg for up to 8 weeks are safe and have anti-stress effects [13].

Interactions

L-theanine may have a negative impact on health when combined with other pharmacological compounds [9].

Therefore, if you are on any other regular medication, it would be a good idea to inform your doctor if you are looking to start taking L-theanine supplements.

Best L-Theanine Weight Loss and Memory Boosting Nootropics 

Here is a quick guide to the best brain-enhancing nootropics for memory and weight loss on the market.

Mind Lab Pro

Mind Lab Pro is a nootropic supplement that has some excellent reviews relating to its effect on mood and focus. It contains 100 mg of L-theanine alongside other plant-based enhancers and a mix of useful vitamins. The Mind Lab Pro review provides you with more detail of its results, but below is a snapshot of its pros and cons.

Pros

• Heightens attention span and focus.
• Enhances energy levels.
• Positive effect on mood.

Cons

• Relatively expensive.
• Does not help you stay awake (though it is not stimulant medication).

NooCube

Similarly, NooCube is an over-the-counter supplement containing 100 mg of L-theanine and other herbs for enhancing focus and productivity. This NooCube review will give you a balance of opinions on the effectiveness of these nootropics for memory.

Pros

• NooCube improves memory.
• Improves mood.
• Impacts focus and concentration.

Cons

• May not have as much of an effect as marketed.

Qualia Mind

Qualia Mind is a blend of amino acid, including green tea extract and vitamins, with a similar goal to the other two nootropics for motivation—to enhance cognitive performance. 

Pros

• Enhances mental clarity.
• Enhances memory and focus.
• Promotes long-term brain health.

Cons

• Relatively expensive.
• It has a lot of ingredients, some of which may not be very beneficial to the brain.

FAQ

Find your key questions about L-theanine answered here.

What Does L-Theanine Do for Anxiety?

L-theanine reduces anxiety by affecting hormones and brain alpha waves. They, in turn, affect the nervous system that leads to a feeling of calm wakefulness.

L-theanine helps with restful sleep too. Its effects on objective sleep quality are known for improving mood and cognition.

How Do You Take Theanine for Anxiety?

L-theanine is from green tea catechins; therefore, you can simply just drink green tea. White and black tea also contain some of it, to a lesser extent.

Alternatively, it can be supplemented as part of a healthy diet with nootropics.

Should You Take L-Theanine at Night?

Yes, it should be fine to take it at night and may even improve sleep quality.

How Long Does It Take for L-Theanine To Start Working?

According to reviews, supplements can start working in as quickly as 20 minutes. Effects may then last up to 10 hours.

However, it would be worth considering incorporating a suitable amount of L-theanine into your dietary habits for a longer-term effect.

Conclusion 

Reviews aside, the science of L-theanine is something we should know about. Eastern cultures have benefited from long-term health for millennia, which could be related to tea consumption. 

Whether you want to boost and impact your cognition quickly through supplementation or are simply inspired to drink more healthy tea, L-theanine would be a great change in your diet for health promotion.

References

1. Reygaert, Wanda C. “Green Tea CATECHINS: Their Use in Treating and PREVENTING Infectious Diseases.” BioMed Research International, Hindawi, 17 July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6076941/. 
2. Li, Chengjian, et al. “L-Theanine Improves Immunity by Altering Th2/th1 Cytokine BALANCE, BRAIN Neurotransmitters, and Expression of Phospholipase C in RAT HEARTS.” Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, International Scientific Literature, Inc., 28 Feb. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4772912/. 
3. Jurgens TM;Whelan AM;Killian L;Doucette S;Kirk S;Foy E; “Green Tea for Weight Loss and Weight Maintenance in Overweight or Obese Adults.” The Cochrane Database of Systematic Reviews, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/23235664/. 
4. Hidese, S., Ogawa, S., Ota, M., Ishida, I., Yasukawa, Z., Ozeki, M., & Kunugi, H. (2019). Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients, 11(10), 2362. https://doi.org/10.3390/nu11102362
5. Baba Y;Inagaki S;Nakagawa S;Kaneko T;Kobayashi M;Takihara T; “Effects of l-Theanine on Cognitive Function in Middle-Aged and Older Subjects: A Randomized Placebo-Controlled Study.” Journal of Medicinal Food, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/33751906/. 
6. Unno K;Hara A;Nakagawa A;Iguchi K;Ohshio M;Morita A;Nakamura Y; “Anti-Stress Effects of Drinking Green Tea with Lowered Caffeine and Enriched Theanine, Epigallocatechin and Arginine on Psychosocial Stress Induced Adrenal Hypertrophy in Mice.” Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/27765356/. 
7. GN;, Nobre AC;Rao A;Owen. “L-Theanine, a Natural Constituent in Tea, and Its Effect on Mental State.” Asia Pacific Journal of Clinical Nutrition, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/18296328/. 
8. Ritsner MS;Miodownik C;Ratner Y;Shleifer T;Mar M;Pintov L;Lerner V; “L-Theanine Relieves Positive, Activation, and Anxiety Symptoms in Patients with Schizophrenia and Schizoaffective Disorder: An 8-Week, Randomized, Double-Blind, Placebo-Controlled, 2-Center Study.” The Journal of Clinical Psychiatry, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/21208586/. 
9. Lopes Sakamoto F;Metzker Pereira Ribeiro R;Amador Bueno A;Oliveira Santos H; “Psychotropic Effects of l-Theanine and Its Clinical Properties: From the Management of Anxiety and Stress to a Potential Use in Schizophrenia.” Pharmacological Research, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/31412272/. 
10. Li, Chengjian, et al. “L-Theanine Improves Immunity by Altering Th2/th1 Cytokine BALANCE, BRAIN Neurotransmitters, and Expression of Phospholipase C in RAT HEARTS.” Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, International Scientific Literature, Inc., 28 Feb. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4772912/. 
11. Zhang, Jun-Ming, and Jianxiong An. “Cytokines, Inflammation, and Pain.” International Anesthesiology Clinics, U.S. National Library of Medicine, 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/. 
12. Kahathuduwa, Chanaka N., et al. “Effects of l-Theanine–Caffeine Combination on Sustained Attention and Inhibitory Control among Children with Adhd: A Proof-of-Concept Neuroimaging Rct.” Nature News, Nature Publishing Group, 4 Aug. 2020, www.nature.com/articles/s41598-020-70037-7. 
13. GN;, Nobre AC;Rao A;Owen. “L-Theanine, a Natural Constituent in Tea, and Its Effect on Mental State.” Asia Pacific Journal of Clinical Nutrition, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/18296328/. 
14. Zhang, Min, et al. “Green Tea Consumption Enhances Survival of Epithelial Ovarian Cancer.” Wiley Online Library, John Wiley & Sons, Ltd, 23 June 2004, onlinelibrary.wiley.com/doi/full/10.1002/ijc.20456. 
15. Miyata, Yasuyoshi, et al. “Anticancer Effects of Green Tea and the Underlying Molecular Mechanisms in Bladder Cancer.” Medicines (Basel, Switzerland), MDPI, 10 Aug. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6164790/. 
16. Polito, Curt Anthony, et al. “Association of Tea Consumption with Risk of Alzheimer’s Disease and ANTI-BETA-AMYLOID Effects of Tea.” Nutrients, MDPI, 22 May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5986534/#sec4-nutrients-10-00655title. 
17. “Gras Notices.” Cfsanappsexternal.fda.gov, www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=GrASNotices&id=209. 
18. Lopes Sakamoto F;Metzker Pereira Ribeiro R;Amador Bueno A;Oliveira Santos H; “Psychotropic Effects of l-Theanine and Its Clinical Properties: From the Management of Anxiety and Stress to a Potential Use in Schizophrenia.” Pharmacological Research, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/31412272/. 

Perhaps you’ve been using Adderall as a study pill, whether you take it every day or during exam periods. Or maybe you have attention-deficit hyperactivity disorder (ADHD) and have been seeking treatment for years. In either case, you tried Adderall and felt like you found the right medication. But now, everything seems to be going wrong. 

Adderall tolerance is a very real and distressing issue. Although you may feel amazing on Adderall, drug tolerance is your brain and liver’s way of protecting you from potentially harmful effects. So how does it happen, and what can we do to reverse it? 

Key Takeaways: Adderall Tolerance

• Adderall is prescribed to treat attention deficit hyperactivity disorder (ADHD) symptoms and is also abused as a study pill.
• It works by increasing dopamine and noradrenaline, which can be life-changing until you develop tolerance.
• Like many drugs, the liver can become more efficient at removing Adderall from the body, reducing the therapeutic benefit.
• Other factors include reduced dopamine production in response to the drug, or even damage to the neurons that make use of the neurotransmitter.
• It is common to need a larger dose of Adderall or other stimulant medication after several months.
• Simple diet and lifestyle changes, alongside nootropic supplements, can help you stick to a low dose or quit Adderall use.

What Is Adderall Tolerance?

Adderall tolerance is an example of the biological process where a previously effective prescription medication becomes less effective over time. In some ways, it is in fact a normal, healthy response to taking a drug for a long period. However, a long-term lack of response could indicate serious issues. 

What Causes Adderall Tolerance?

How Adderall works is through an increase of your levels of dopamine, noradrenaline, and certain other neurotransmitters, such as serotonin [1]. Your body responds to this by turning down the production of these neurotransmitters. This is why missing a dose, or Adderall withdrawal, can leave you feeling terrible. 

The vast majority of physiological processes are controlled by negative feedback loops. High levels of substances such as neurotransmitters or hormones will then turn their production down, so they don’t reach dangerously high concentrations. While it’s easy to feel like your body is betraying you, this is a protective response. 

Additionally, with repeated exposure to certain substances, your liver ramps up detoxification. You may remember your first time trying alcohol, and how you were much more sensitive then than now. Or, if you don’t drink often, you’re more sensitive than your friends who drink regularly. This is because the parts of your liver cells that produce detoxification enzymes increase in number, as a specific response to Adderall [2]. 

Research suggests that tolerance is more likely with continuous doses of the drug, instead of occasional high doses. Shorter-term high doses are often used in animal research to test the effects of long-term Adderall use, but continuous smaller doses are more relevant to how we actually take the drug [3]. 

Why Is My Adderall Not Working Anymore?

A gradual, persistent loss of response to Adderall could indicate something more serious. Lab research points to the possibility that real-world doses of the drug may eventually damage dopaminergic neurons. Both dopamine and dopamine transporters significantly declined in primates taking realistic Adderall doses. 

This could stop you from responding to the drug, as you aren’t making enough dopamine for it to work with. However, children seem to be better protected and may not build tolerance through this mechanism. As more children use Adderall than adults, we haven’t picked up this adverse effect yet [4].

Damage to the neurons may be partly caused by high levels of cortisol. If you miss a dose of Adderall, or worse, go through the Adderall crash, cortisol rises in response to the sudden fall in dopamine. Through oxidative stress, cortisol not only damages the neurons you already have but also impairs the growth and development of new ones [5] [6]. 

Research comparing amphetamined drugs (tested with MDMA), Ritalin, and modafinil found that, out of the three prescription stimulants, only the amphetamines raised cortisol. 

While the placebo group’s cortisol levels were only 630nmol/L, those taking MDMA had an average cortisol concentration of 942nmol/L. MDMA is a stronger, illegal amphetamine, but Adderall may have a milder effect [7]. 

Adderall Tolerance Build Up: What To Know

Your body gets used to Adderall sooner than you think, but the most important thing is to stay safe. 

How Long Does It Take for Adderall Tolerance?

The early signs of Adderall tolerance may even start within a few days. A study involving healthy men and women, with no ADHD or other disorder, showed the beginnings of tolerance after only three doses spread over five days. Just one dose significantly increased blinking rate, but after the third, this fell back to levels seen in the placebo group. 

On the other hand, energy (measured as vigor) was higher after three doses than one alone. This means that while you develop a tolerance early, you are unlikely to see any negative effects of this for quite some time [8]. 

Noticeable Adderall tolerance can take weeks or months to appear. A study involving children with ADHD taking Ritalin, another stimulant, showed that the average child needed one or two dosage increases over the course of 10 months. 

For children taking ADHD every day, there was an average of 1.79 dosage increases. However, having an “Adderall holiday” on the weekends reduced this down to 1.61 increases in their dose. 

This means occasionally using the drug as a study pill, or reserving it for the most difficult periods of the semester, is less likely to cause tolerance. If you have ADHD, taking breaks could mean you will reach tolerance to your current dose a little slower, but use caution to avoid Adderall withdrawal symptoms [9]. 

What Adderall Dosage Works Best?

If you need stimulants for medical reasons, do not use larger doses of Adderall than what has been prescribed to you. The upper limit for the drug is set at 40 mg per day for ADHD symptoms, and up to 60 mg per day for narcolepsy. The right dose for you depends on how well you respond to Adderall. Only your doctor can determine this, as it is individual [1]. 

In research revealing tolerance through a loss of dopaminergic neurons, the response of the serotonin system was unchanged. One of the dangers of Adderall is therefore the perceived need to take higher doses because you could be at risk of serotonin syndrome. 

Depending on the severity, serotonin syndrome can involve anything from a faster heart rate and rest under medical supervision, to organ damage and intensive care [10]. 

How To Make Adderall Work Again: 6 Simple Tips

If you’re missing the benefits of Adderall, there are simple ways to make your ADHD drugs work better for you again without turning to Adderall abuse. You may have been eating foods that impair absorption, leading to an easy misunderstanding that the stimulant medications have stopped working. 

On the other hand, there is hope if your dopaminergic systems have been burnt out by stimulant medication use. While impaired dopamine responses have been documented up to three years after quitting the drug, they slowly improve even without intervention [11]. 

1. Stay Hydrated

Dehydration can make you feel terrible and increase cortisol levels [12]. The discomfort of dehydration may paint a higher dose of Adderall in a more tempting light, while cortisol contributes to brain cell damage. What’s more, a tall glass of water alongside Adderall can dilute your stomach acid, which aids absorption [1]. 

2. Avoid Citrus Juice

Dietary acids, such as citric acid, are known to reduce the absorption of amphetamines from the intestines and into the bloodstream. All citrus fruits are particularly rich in these, so it’s best to avoid them and even more so around the time when you take your medication [1]. 

3. Don’t Miss Breakfast

It doesn’t matter how busy you are; don’t skip meals, including breakfast. Taking Adderall on an empty stomach may reduce its absorption as your digestive system’s pH is more acidic. 

Some nutrients can aid neurotransmitter systems too. For example, choline may increase your levels of dopamine receptors in the reward system [13]. Eggs are one of the best natural sources of choline, whether they are fried, scrambled, or boiled. 

4. Avoid Vitamin C in the Evenings

The technical term for vitamin C is ascorbic acid—yes, it’s an acid too! Like citric acid, it can impair the absorption of amphetamines such as Adderall. Do not take vitamin C near your dose of Adderall; if you need both, separate them by a few hours [1]. 

5. Develop Healthy Sleep Patterns

Healthy sleeping patterns keep your levels of cortisol within the correct rhythms. This protects your brain against damage in the long term and can assist in the restoration of neurotransmitter systems as a result. 

What’s more, you are likely to feel better mentally. A common psychological cause of taking Adderall is a lack of coping skills and self-care, as stimulant drugs may be seen as all you need [14]. Making healthy lifestyle choices now could improve your overall wellbeing and prevent Adderall addiction to fill the gaps.

6. Know When To See a Doctor

If your ADHD symptoms are returning to their pre-medication state, and you’re still taking Adderall at the recommended dose, it’s best to see a doctor. It may be tempting to experiment with higher doses, but this can be dangerous, especially without medical supervision. 

Sometimes, it may be best for you to have a break from taking Adderall (and possibly other stimulant medication) or change over to other drugs entirely. Adderall is often recommended for shorter-term use only due to potential long-term effects [1]. 

Adderall Tolerance Reset Supplements

If you want to prevent Adderall tolerance or take low doses instead, there are nootropic supplements that can help increase dopamine and noradrenaline. This means they can prevent you from developing tolerance, compensate for falling Adderall efficacy, or even replace the drugs altogether. As a result, they are often described as OTC Adderall, or natural Adderall. 

Many people who abuse Adderall also prefer to transition onto nootropics to benefit neurological health and prevent future substance abuse as they are not addictive. If this is you, a medically supervised tapering program may still be necessary, especially if you take a high dose.

Mind Lab Pro

Mind Lab Pro is a comprehensive nootropic stack with 11 ingredients targeting the underlying drivers of healthy brain function. 

Some, such as Bacopa monnieri, assist in the production of dopamine and noradrenaline [15]. Citicoline is a safer supplemental version of choline, which helps to increase dopamine receptor counts [13]. These benefits can help prevent tolerance to Adderall and keep you at your original dose, or soothe withdrawal symptoms if you want to quit abusing Adderall.

Other ingredients can deal with the consequences of long-term stimulant treatment for ADHD or drug abuse to help you feel normal. For example, lion’s mane is a widely appreciated brain and nerve regenerator, able to boost cognition by supporting the growth and development of new brain cells [16]. 

For more information, read the full Mind Lab Pro review here. 

Performance Lab 

Performance Lab is a streamlined nootropic that still hits all the right targets if you want to manage your ADHD symptoms more effectively, or no longer abuse Adderall. It contains tyrosine, citicoline, phosphatidylserine, and maritime pine bark extract. 

Phosphatidylserine can help you recover from Adderall misuse or other stimulant drug abuse by assisting the repair of neurons [17]. Maritime pine bark is a potent antioxidant, able to end the cycle of oxidative stress and cell damage seen with high cortisol or neurotransmitter toxicity [18]. 

See this Performance Lab Nootropics review for everything you need to know. 

FAQ

What are the most important things we need to know about Adderall tolerance?

Does Adderall Become Less Effective Over Time?

ADHD medications, including Adderall, begin losing their potency within a few days. This will likely begin as reduced severity of side effects, but it is common to need an increased dose after several weeks or months. 

Does Adderall Cause Drug Tolerance?

Both normal physiological processes and Adderall itself cause you to develop a tolerance. The same mechanisms of liver detoxification that make you more able to handle alcohol can also cause you to metabolize Adderall faster. By dialing down dopamine signaling and potentially causing neurotoxicity, taking the drug every day for long periods leads to tolerance too.  

Can You Build a Tolerance To Amphetamines?

Research described above has demonstrated a tolerance through the dopaminergic pathways, but the serotonergic system does not necessarily follow. With a partial tolerance, you may still be vulnerable to serotonin syndrome symptoms if you increase your dose without supervision or past the safe range. 

Conclusion

Adderall tolerance is the result of several biological processes where your detoxification ability speeds up, neurotransmitter production falls, and dopaminergic systems face potential damage. If your study success is falling back into a nightmare, nootropic supplements can be a safer, more effective alternative to the drug.

If you require stimulant medication, there are ways you can maintain the drug’s therapeutic effects. Through nootropic supplements, keeping healthy lifestyle habits, and managing stomach acidity around your Adderall doses, you can stay on top of your ADHD symptoms. 

References:

1. U.S. Food and Drug Administration. “Adderall.” (2017) https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/011522s043lbl.pdf 
2. Tortora, Gerald J. & Derrickson, B. “Principles of anatomy & physiology.” Wiley (2011).
3. Turner, Amy C et al. “Repeated intermittent oral amphetamine administration results in locomotor tolerance not sensitization.” Journal of psychopharmacology (Oxford, England) vol. 32,8 (2018): 949-954. doi:10.1177/0269881118763984 
4. Ricaurte, George A et al. “Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates.” The Journal of pharmacology and experimental therapeutics vol. 315,1 (2005): 91-8. doi:10.1124/jpet.105.087916
5. Bray, Brenna, et al. “Amphetamine withdrawal differentially affects hippocampal and peripheral corticosterone levels in response to stress.” Brain Research, 1644, (2016): 278–287. doi:10.1016/j.brainres.2016.05.030 
6. de Souza-Talarico, Juliana Nery et al. “Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging.” Dementia & neuropsychologia vol. 5,1 (2011): 8-16. doi:10.1590/S1980-57642011DN05010003 
7. Dolder, Patrick C et al. “Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects.” Psychopharmacology vol. 235,2 (2018): 467-479. doi:10.1007/s00213-017-4650-5 
8. Strakowski, S M et al. “Human response to repeated low-dose d-amphetamine: evidence for behavioral enhancement and tolerance.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 25,4 (2001): 548-54. doi:10.1016/S0893-133X(01)00253-6 
9. Pelham, William E, and James M Swanson. “Examining Tolerance to CNS Stimulants in ADHD.” Clinicaltrials.gov, 22 Jan. 2013, clinicaltrials.gov/ProvidedDocs/08/NCT02039908/Prot_SAP_000.pdf.
10. Wang, Robert Z et al. “Serotonin syndrome: Preventing, recognizing, and treating it.” Cleveland Clinic journal of medicine vol. 83,11 (2016): 810-817. doi:10.3949/ccjm.83a.15129 
11. Hayley, Amie C et al. “Amphetamine-induced alteration to gaze parameters: A novel conceptual pathway and implications for naturalistic behavior.” Progress in neurobiology vol. 199 (2021): 101929. doi:10.1016/j.pneurobio.2020.101929 
12. Zaplatosch, Mitchell E, and William M Adams. “The Effect of Acute Hypohydration on Indicators of Glycemic Regulation, Appetite, Metabolism and Stress: A Systematic Review and Meta-Analysis.” Nutrients vol. 12,9 2526. 20 Aug. 2020, doi:10.3390/nu12092526 
13. Giménez, R et al. “Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice.” British journal of pharmacology vol. 104,3 (1991): 575-8. doi:10.1111/j.1476-5381.1991.tb12471.x
14. Yanofski, Jason. “The Dopamine Dilemma-Part II: Could Stimulants Cause Tolerance, Dependence, and Paradoxical Decompensation?.” Innovations in clinical neuroscience vol. 8,1 (2011): 47-53.
15. Aguiar, Sebastian, and Thomas Borowski. “Neuropharmacological review of the nootropic herb Bacopa monnieri.” Rejuvenation research vol. 16,4 (2013): 313-26. doi:10.1089/rej.2013.1431 
16. Friedman, Mendel. “Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion’s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds.” Journal of agricultural and food chemistry vol. 63,32 (2015): 7108-23. doi:10.1021/acs.jafc.5b02914 
17. Naftelberg, Shiran et al. “Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.” Neural regeneration research vol. 12,4 (2017): 534-537. doi:10.4103/1673-5374.205082 
18. Malekahmadi, Mahsa et al. “The effect of French maritime pine bark extract supplementation on inflammation, nutritional and clinical status in critically ill patients with traumatic brain injury: A randomized controlled trial.” Phytotherapy research : PTR, 10.1002/ptr.7187. 12 Aug. 2021, doi:10.1002/ptr.7187